About: Immunogenicity and protective potency of Norovirus GII.17 virus-like particle-based vaccine

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About: Immunogenicity and protective potency of Norovirus GII.17 virus-like particle-based vaccine Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immunogenicity and protective potency of Norovirus GII.17 virus-like particle-based vaccine
Creator	Kang, Wei Congwen, Shao Rongliang, Yuan Shenrong, Jing
Source	PMC
abstract	OBJECTIVES: Noroviruses (NoVs) are major cause of acute viral gastroenteritis in worldwide, and the lack of a cell culture system that must be considered the virus like particles (VLPs) are used as an effective vaccine development. MATERIALS AND METHODS: In the present study, we investigated the expression of the major capsid protein (VP1) of the Genogroup II, genotype 17 (GII.17) NoV, using recombinant baculovirus system in insect cells, as well as a saliva binding blockade assay to detect their protective potency. RESULTS: Our results showed that GII.17 VLPs could be successfully generated in sf9 insect cells, and electron microscopic revealed that GII.17 VLPs appeared as spherical particles with a − 35 nm diameter. Immunized mice with purified VLPs produced GII.17 specific sera and could efficiently block GII.17 VLPs binding to the saliva histo-blood group antigens (HBGAs). CONCLUSIONS: Together, these results suggested that GII.17 VLPs represent a promising vaccine candidate against NoV GII.17 infection and strongly support further preclinical and clinical studies.
has issue date	2020-02-22(xsd:dateTime)
bibo:doi	10.1007/s10529-020-02837-w
bibo:pmid	32088791
has license	no-cc
sha1sum (hex)	83e7619e70e57e3f10a6c84229e6d69011f894ee
schema:url	https://doi.org/10.1007/s10529-020-02837-w
resource representing a document's title	Immunogenicity and protective potency of Norovirus GII.17 virus-like particle-based vaccine
has PubMed Central identifier	PMC7223773
has PubMed identifier	32088791
schema:publication	Biotechnol Lett
resource representing a document's body	covid:83e7619e70e57e3f10a6c84229e6d69011f894ee#body_text
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