About: Beneficial effects of Houttuynia cordata polysaccharides on “two-hit” acute lung injury and endotoxic fever in rats associated with anti-complementary activities

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About: Beneficial effects of Houttuynia cordata polysaccharides on “two-hit” acute lung injury and endotoxic fever in rats associated with anti-complementary activities Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Beneficial effects of Houttuynia cordata polysaccharides on “two-hit” acute lung injury and endotoxic fever in rats associated with anti-complementary activities
Creator	Chen, Daofeng Lu, Yan Jiang, Yun Li, Hong Ling, Lijun Zhang, Yunyi
Source	Elsevier; Medline; PMC
abstract	Houttuynia cordata Thunb. is a traditional herb used for clearing heat and eliminating toxins, and has also been used for the treatment of severe acute respiratory syndrome (SARS). In vitro, the crude H. cordata polysaccharides (CHCP) exhibited potent anti-complementary activity through both the classical and alternative pathways by acting on components C3 and C4 of the complement system without interfering with the coagulation system. This study was to investigate the preventive effects of CHCP on acute lung injury (ALI) induced by hemorrhagic shock plus lipopolysaccharide (LPS) instillation (two-hit) and LPS-induced fever in rats. CHCP significantly attenuated pulmonary injury in the “two-hit” ALI model by reducing pulmonary edema and protein exudation in bronchoalveolar lavage fluid (BALF). In addition, it reduced the deposit of complement activation products in the lung and improved oxidant-antioxidant imbalance. Moreover, CHCP administration inhibited fever in rats, reduced the number of leukocytes and restored serum complement levels. The inhibition on the inappropriate activation of complement system by CHCP may play an important role in its beneficial effects on inflammatory diseases. The anti-complementary polysaccharides are likely to be among the key substances for the heat-clearing function of H. cordata.
has issue date	2017-12-08(xsd:dateTime)
bibo:doi	10.1016/j.apsb.2017.11.003
bibo:pmid	29719782
has license	cc-by-nc-nd
sha1sum (hex)	83cfd4e4f2ba744bccc85d7da2fe54157ee19136
schema:url	https://doi.org/10.1016/j.apsb.2017.11.003
resource representing a document's title	Beneficial effects of Houttuynia cordata polysaccharides on “two-hit” acute lung injury and endotoxic fever in rats associated with anti-complementary activities
has PubMed Central identifier	PMC5925397
has PubMed identifier	29719782
schema:publication	Acta Pharm Sin B
resource representing a document's body	covid:83cfd4e4f2ba744bccc85d7da2fe54157ee19136#body_text
is schema:about of	named entity 'clearing' named entity 'acute lung injury' named entity 'This' named entity 'alternative' named entity 'pathways' named entity 'reduced' named entity 'ALI' covid:arg/83cfd4e4f2ba744bccc85d7da2fe54157ee19136 named entity 'inhibition' named entity 'study' named entity 'levels' named entity 'activation' named entity 'imbalance' named entity 'Houttuynia' named entity 'substances' named entity 'potent' named entity 'coagulation system' named entity 'attenuated' named entity 'acute lung injury' named entity 'ALI' named entity 'bronchoalveolar lavage fluid' named entity 'LPS' named entity 'lipopolysaccharide' named entity 'BALF' named entity 'ALI' named entity 'Houttuynia cordata' named entity 'polysaccharides' named entity 'protein' named entity 'effects' named entity 'interstitial infiltration' named entity 'Hemorrhagic shock' named entity 'endotoxin' named entity '1:64' named entity 'Body temperature' named entity 'infusion' named entity 'adverse effects' named entity 'endothelial' named entity 'heparin' named entity 'significant effect' named entity 'galactose' named entity 'trichloroacetic acid' named entity 'supernatants' named entity 'BALF' named entity 'Platelet' named entity 'life-threatening' named entity 'erythrocyte' named entity 'lung' named entity 'C1q' named entity 'ANOVA' named entity 'normal range' named entity 'total protein' named entity 'lungs' named entity 'H&E' named entity 'precipitate' named entity 'carbohydrate' named entity 'hemolytic' named entity 'BALF' named entity 'severe acute respiratory syndrome' named entity 'protein' named entity 'leukocytes' named entity '37°C' named entity 'neutrophils' named entity 'body temperature' named entity 'ALI' named entity 'polysaccharides' named entity 'H&E' named entity 'centrifuged' named entity 'LPS' named entity 'hypotensive' named entity 'fever' named entity 'complement activation' named entity 'left lung' named entity 'anesthetized' named entity 'serum' named entity 'hemolysis' named entity 'capillary'

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