About: Coronavirus derived expression systems

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Coronavirus derived expression systems
Creator	Enjuanes, Luis Sola, Isabel Escors, David Almazan, Fernando Ortego, Javier Riquelme, Cristina Alonso, Sara Izeta, Ander Calvo, Enrique Sanchez, Carlos Sanchez, Jose Gonzalez, Jose
Source	Elsevier; Medline; PMC
abstract	Abstract Both helper dependent expression systems, based on two components, and single genomes constructed by targeted recombination, or by using infectious cDNA clones, have been developed. The sequences that regulate transcription have been characterized mainly using helper dependent expression systems and it will now be possible to validate them using single genomes. The genome of coronaviruses has been engineered by modification of the infectious cDNA leading to an efficient (>20 μg ml−1) and stable (>20 passages) expression of the foreign gene. The possibility of engineering the tissue and species tropism to target expression to different organs and animal species, including humans, increases the potential of coronaviruses as vectors. Thus, coronaviruses are promising virus vectors for vaccine development and, possibly, for gene therapy.
has issue date	2001-07-12(xsd:dateTime)
bibo:doi	10.1016/s0168-1656(01)00281-4
bibo:pmid	11434966
has license	els-covid
sha1sum (hex)	83a5cb9fca2a2cbcd33ec7b1039bb514fae49095
schema:url	https://doi.org/10.1016/s0168-1656%2801%2900281-4
resource representing a document's title	Coronavirus derived expression systems
has PubMed Central identifier	PMC7126887
has PubMed identifier	11434966
schema:publication	Journal of Biotechnology
resource representing a document's body	covid:83a5cb9fca2a2cbcd33ec7b1039bb514fae49095#body_text
is schema:about of	named entity 'CORONAVIRUS' named entity 'development' named entity 'SEQUENCES' named entity 'SYSTEMS' named entity 'INCREASES' named entity 'POSSIBLE' named entity 'TROPISM' named entity 'FOREIGN GENE' named entity 'LEADING' named entity 'BASED' named entity 'TARGET' named entity 'CLONES' named entity 'MG ML' named entity 'SPECIES' named entity 'HAVE' named entity 'SYSTEMS' named entity 'GENE THERAPY' named entity 'POTENTIAL' named entity 'SINGLE' named entity 'ANIMAL SPECIES' named entity 'VACCINE DEVELOPMENT' named entity 'ORGANS' named entity 'CHARACTERIZED' named entity 'COMPONENTS' named entity 'USING' named entity 'INFECTIOUS' named entity 'DIFFERENT' named entity 'STABLE' named entity 'RECOMBINATION' named entity 'EFFICIENT' named entity 'REGULATE' named entity 'EXPRESSION' named entity 'DEPENDENT' named entity 'TRANSCRIPTION' named entity 'VECTORS' named entity 'ENGINEERED' named entity 'INCLUDING' named entity 'CONSTRUCTED' named entity 'TISSUE' named entity 'CORONAVIRUSES' named entity 'CDNA' named entity 'ENGINEERING' named entity 'GENOME' named entity 'GENOMES' named entity 'VIRUS' named entity 'TARGETED' named entity 'MODIFICATION' named entity 'DERIVED' named entity 'EXPRESSION' named entity 'HUMANS' covid:arg/83a5cb9fca2a2cbcd33ec7b1039bb514fae49095 named entity 'dependent' named entity 'regulate' named entity 'genomes' named entity 'target' named entity 'expression' named entity 'cDNA' named entity 'genomes' named entity 'expression systems' named entity 'cDNA' named entity 'coronaviruses' named entity 'gene therapy' named entity 'coronaviruses' named entity 'cDNA clones' named entity 'virus' named entity 'expression systems' named entity 'regulate transcription' named entity 'expression' named entity 'RNA' named entity 'IRES'

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