About: Transmissible gastroenteritis virus N protein causes endoplasmic reticulum stress, up-regulates interleukin-8 expression and its subcellular localization in the porcine intestinal epithelial cell

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About: Transmissible gastroenteritis virus N protein causes endoplasmic reticulum stress, up-regulates interleukin-8 expression and its subcellular localization in the porcine intestinal epithelial cell Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Transmissible gastroenteritis virus N protein causes endoplasmic reticulum stress, up-regulates interleukin-8 expression and its subcellular localization in the porcine intestinal epithelial cell
Creator	Zhang, Qi Tong, Dewen Xu, Xingang Xu, Ying Chang, Rong
Source	Elsevier; Medline; PMC
abstract	Abstract This essay focuses on transmissible gastroenteritis virus (TGEV), which is an enteropathogenic virus related to contagious and acute diseases in suckling piglets. Previous literature suggests that the TGEV nucleocapsid protein (N) plays a significant role in viral transcriptional process, however, there is a need to examine other functions of TGEV N protein in the porcine intestinal epithelial cell (IEC) which is the target cell of TGEV. In the present study, we investigated the degradation, subcellular localisation, and function of TGEV N protein by examining its effects on cycle progression, endoplasmic reticulum (ER) stress, interleukin-8 (IL-8) expression, and cell survival. The results showed that TGEV N protein localised in the cytoplasm, inhibited IEC growth, prolonged the S-phase cell cycle by down-regulating cell cycle protein cyclin A, and was mainly degraded through the proteasome pathway. Moreover, TGEV N protein induced ER stress and activated NF-κB, which was responsible for the up-regulation of IL-8 and Bcl-2 expression. This report mainly considers the functions of TGEV N protein in IEC. To be specific, in IEC, TGEV N protein induces cell cycle prolongation at the S-phase, ER stress and up-regulates IL-8 expression. These results provide a better understanding of the functions and structural mechanisms of TGEV N protein.
has issue date	2018-08-31(xsd:dateTime)
bibo:doi	10.1016/j.rvsc.2018.06.008
bibo:pmid	29909129
has license	els-covid
sha1sum (hex)	8397db5938687c5e7758d30c3fb75aba0237f3cc
schema:url	https://doi.org/10.1016/j.rvsc.2018.06.008
resource representing a document's title	Transmissible gastroenteritis virus N protein causes endoplasmic reticulum stress, up-regulates interleukin-8 expression and its subcellular localization in the porcine intestinal epithelial cell
has PubMed Central identifier	PMC7111826
has PubMed identifier	29909129
schema:publication	Research in Veterinary Science
resource representing a document's body	covid:8397db5938687c5e7758d30c3fb75aba0237f3cc#body_text
is schema:about of	named entity 'CELL CYCLE PROTEIN' named entity 'STUDY' named entity 'BAB' named entity 'IL-8' named entity 'THESE' named entity 'RESPONSIBLE' named entity 'PRESENT' named entity 'MECHANISMS' named entity 'DEGRADED' named entity 'UP-REGULATES' named entity 'REGULATING' named entity 'CYCLIN A' named entity 'PROLONGED' named entity 'VIRAL' named entity 'porcine' named entity 'IEC' named entity 'intestinal' named entity 'SUBCELLULAR LOCALIZATION' covid:arg/8397db5938687c5e7758d30c3fb75aba0237f3cc named entity 'BCL-2' named entity 'PROGRESSION' named entity 'ACUTE DISEASES' named entity 'REPORT' named entity 'UNDERSTANDING' named entity 'TRANSMISSIBLE GASTROENTERITIS VIRUS' named entity 'TO EXAMINE' named entity 'INHIBITED' named entity 'EXPRESSION' named entity 'PORCINE' named entity 'INTESTINAL EPITHELIAL CELL' named entity 'ENDOPLASMIC RETICULUM STRESS' named entity 'GROWTH' named entity 'PROVIDE' named entity 'EFFECTS' named entity 'INVESTIGATED' named entity 'SIGNIFICANT' named entity 'EXAMINING' named entity 'PROTEASOME PATHWAY' named entity 'ENDOPLASMIC RETICULUM' named entity 'LOCALISED' named entity 'S-PHASE' named entity 'NUCLEOCAPSID PROTEIN' named entity 'CYTOPLASM' named entity 'N PROTEIN' named entity 'PROTEIN ' named entity 'ITS' named entity 'TRANSMISSIBLE GASTROENTERITIS VIRUS' named entity 'FUNCTION' named entity 'RELATED' named entity 'ACTIVATED' named entity 'IS A' named entity 'STRESS' named entity 'ENTEROPATHOGENIC VIRUS' named entity 'INTERLEUKIN-8 ' named entity 'TARGET CELL' named entity 'LOCALISATION' named entity 'ITS' named entity 'BETTER' named entity 'INTESTINAL EPITHELIAL CELL' named entity 'ESSAY' named entity 'PORCINE' named entity 'PROCESS' named entity 'CELL SURVIVAL' named entity 'INTERLEUKIN-8 ' named entity 'CAUSES' named entity 'UP-REGULATES' named entity 'LITERATURE' named entity 'EXPRESSION' named entity 'STRUCTURAL' named entity 'INDUCED' named entity 'IEC' named entity 'DEGRADATION' named entity 'CYCLE' named entity 'RESULTS' named entity 'PROTEIN ' named entity 'PLAYS' named entity 'THE UP'

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