About: Molecular profiling of oral microbiota in jawbone samples of bisphosphonate‐related osteonecrosis of the jaw

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About: Molecular profiling of oral microbiota in jawbone samples of bisphosphonate‐related osteonecrosis of the jaw Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Molecular profiling of oral microbiota in jawbone samples of bisphosphonate‐related osteonecrosis of the jaw
Creator	Wong, C Li, Y Bohle, G Doty, S Estilo, C Farooki, A Fornier, M Huryn, J Pushalkar, S Saxena, D Wei, X
source	PMC
abstract	Oral Diseases (2012) 18, 602–612 Objective: Infection has been hypothesized as a contributing factor to bisphosphonate (BP)‐related osteonecrosis of the jaw (BRONJ). The objective of this study was to determine the bacterial colonization of jawbone and identify the bacterial phylotypes associated with BRONJ. Materials and methods: Culture‐independent 16S rRNA gene‐based molecular techniques were used to determine and compare the total bacterial diversity in bone samples collected from 12 patients with cancer (six, BRONJ with history of BP; six, controls without BRONJ, no history of BP but have infection). Results: Denaturing gradient gel electrophoresis profile and Dice coefficient displayed a statistically significant clustering of profiles, indicating different bacterial population in BRONJ subjects and control. The top three genera ranked among the BRONJ group were Streptococcus (29%), Eubacterium (9%), and Pseudoramibacter (8%), while in the control group were Parvimonas (17%), Streptococcus (15%), and Fusobacterium (15%). H&E sections of BRONJ bone revealed layers of bacteria along the surfaces and often are packed into the scalloped edges of the bone. Conclusion: This study using limited sample size indicated that the jawbone associated with BRONJ was heavily colonized by specific oral bacteria and there were apparent differences between the microbiota of BRONJ and controls.
has issue date	2012-03-23(xsd:dateTime)
bibo:doi	10.1111/j.1601-0825.2012.01916.x
bibo:pmid	22443347
has license	no-cc
sha1sum (hex)	837a3961f799d7ab0b2009591417e6d45bebe1d4
schema:url	https://doi.org/10.1111/j.1601-0825.2012.01916.x
resource representing a document's title	Molecular profiling of oral microbiota in jawbone samples of bisphosphonate‐related osteonecrosis of the jaw
has PubMed Central identifier	PMC7167636
has PubMed identifier	22443347
schema:publication	Oral Dis
resource representing a document's body	covid:837a3961f799d7ab0b2009591417e6d45bebe1d4#body_text
is schema:about of	named entity 'samples' named entity 'profiling' named entity 'Aghaloo' named entity 'Bio-Rad' named entity '16S rDNA' named entity 'septic arthritis' named entity 'gram-negative' named entity 'toxicity' named entity 'BRONJ' named entity 'PCR-amplified' named entity 'Sheffield' named entity 'bone infection' named entity 'BRONJ' named entity 'Sequence data' named entity 'phyla' named entity 'severe anemia' named entity 'BRONJ' named entity 'diversity indices' named entity 'BRONJ' named entity 'maxillary sinusitis' named entity 'lesion' named entity 'E. coli' named entity 'osseous' named entity 'Streptococcus' named entity 'biofilm' named entity 'gene' named entity 'BRONJ' named entity 'Streptococcus' named entity 'control group' named entity 'Fusobacteria' named entity 'BRONJ' named entity 'DGGE' named entity 'clones' named entity 'formalin' named entity 'denaturation' named entity 'resorptive' named entity 'antiangiogenic' named entity 'head and neck' named entity 'PCR' named entity 'ulceration' named entity 'pathogenesis' named entity 'bone matrix' named entity 'gene' named entity 'Mogibacterium' named entity 'amino acid' named entity 'butyric' named entity 'dNTP' named entity 'Applied Maths' named entity 'BRONJ' named entity 'oral cavity' named entity 'amplicon' named entity 'biofilm' named entity 'intravenous' named entity 'BRONJ' named entity 'bacterial infections' named entity 'bone infections' named entity 'periodontal disease' named entity 'Memorial Sloan-Kettering Cancer Center' named entity 'bone necrosis' named entity 'denaturation' named entity 'standard of care' named entity 'probability' named entity 'Fusobacteria' named entity 'BRONJ' named entity 'ischemia' named entity 'metastatic cancer' named entity 'necrotic' named entity 'Proteobacteria' named entity 'soft tissue' named entity 'BRONJ' named entity 'Streptococcus mitis'

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