About: A structural view of coronavirus

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About: A structural view of coronavirus–receptor interactions Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A structural view of coronavirus–receptor interactions
Creator	Mudgal, Gaurav Reguera, Juan Santiago, César Casasnovas, José
Source	Elsevier; Medline; PMC
abstract	Abstract In the coronavirus (CoV), the envelope spike (S) glycoprotein is responsible for CoV cell entry and host-to-host transmission. The S is a multifunctional glycoprotein that mediates both attachment of CoV particles to cell surface receptor molecules as well as membrane penetration by fusion. Receptor-binding domains (RBD) have been identified in the S of diverse CoV; they usually contain antigenic determinants targeted by antibodies that neutralize CoV infections. To penetrate host cells, the CoV can use various cell surface molecules, although they preferentially bind to ectoenzymes. Several crystal structures have determined the folding of CoV RBD and the mode by which they recognize cell entry receptors. Here we review the CoV–receptor complex structures reported to date, and highlight the distinct receptor recognition modes, common features, and key determinants of the binding specificity. Structural studies have established the basis for understanding receptor recognition diversity in CoV, its evolution and the adaptation of this virus family to different hosts. CoV responsible for recent outbreaks have extraordinary potential for cross-species transmission; their RBD bear large platforms specialized in recognition of receptors from different species, which facilitates host-to-host circulation and adaptation to man.
has issue date	2014-12-19(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2014.10.005
bibo:pmid	25451063
has license	els-covid
sha1sum (hex)	834f268f16aa77c2b85de55125d528b6a110dd9a
schema:url	https://doi.org/10.1016/j.virusres.2014.10.005
resource representing a document's title	A structural view of coronavirus–receptor interactions
has PubMed Central identifier	PMC7114462
has PubMed identifier	25451063
schema:publication	Virus Research
resource representing a document's body	covid:834f268f16aa77c2b85de55125d528b6a110dd9a#body_text
is schema:about of	named entity 'modes' named entity 'cells' named entity 'RECEPTOR INTERACTIONS' named entity 'FEATURES' named entity 'SPIKE' named entity 'FOLDING' named entity 'RECEPTOR COMPLEX' named entity 'ANTIGENIC DETERMINANTS' named entity 'BEAR' named entity 'EVOLUTION' named entity 'REPORTED' named entity 'CELL SURFACE RECEPTOR' named entity 'FAMILY' named entity 'RECEPTORS' named entity 'UNDERSTANDING' named entity 'HOST' named entity 'ANTIBODIES' named entity 'RECEPTOR' named entity 'ADAPTATION' named entity 'IDENTIFIED' named entity 'VIRUS' named entity 'DETERMINANTS' named entity 'STRUCTURES' named entity 'VIEW' named entity 'CORONAVIRUS' named entity 'PENETRATION' named entity 'CONTAIN' named entity 'DIVERSE' named entity 'OUTBREAKS' named entity 'RESPONSIBLE' named entity 'USE' named entity 'MEMBRANE' named entity 'CIRCULATION' named entity 'MAN' named entity 'CELL' named entity 'ENTRY' named entity 'BIND' named entity 'THEIR' named entity 'ATTACHMENT' named entity 'INFECTIONS' named entity 'MEDIATES' named entity 'CRYSTAL' named entity 'ESTABLISHED' named entity 'DISTINCT' named entity 'DIFFERENT' named entity 'SPECIALIZED' named entity 'MOLECULES' named entity 'PENETRATE' named entity 'BINDING SPECIFICITY' named entity 'POTENTIAL' named entity 'IS A' named entity 'BINDING' named entity 'RECOGNIZE' named entity 'TRANSMISSION' named entity 'STRUCTURAL' named entity 'STRUCTURAL' named entity '28S' named entity 'REVIEW' named entity 'BASIS' named entity 'SPECIES' named entity 'RECEPTOR RECOGNITION' named entity 'COMMON' named entity 'STUDIES' named entity 'KEY' named entity 'MODE' named entity 'DATE' named entity 'TARGETED' named entity 'HERE' named entity 'RBD' named entity 'HAVE' named entity 'USUALLY' named entity 'DIVERSITY' named entity 'VARIOUS' named entity 'ITS' named entity 'RECENT' named entity 'RECOGNITION' named entity 'FUSION' named entity 'LARGE'

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