About: A Novel Vaccine against Crimean-Congo Haemorrhagic Fever Protects 100% of Animals against Lethal Challenge in a Mouse Model

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About: A Novel Vaccine against Crimean-Congo Haemorrhagic Fever Protects 100% of Animals against Lethal Challenge in a Mouse Model Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A Novel Vaccine against Crimean-Congo Haemorrhagic Fever Protects 100% of Animals against Lethal Challenge in a Mouse Model
Creator	Miloszewska, A Rayner, E Buttigieg, K Dowall, S Findlay-Wilson, S
Source	PMC
abstract	Crimean-Congo Haemorrhagic Fever (CCHF) is a severe tick-borne disease, endemic in many countries in Africa, the Middle East, Eastern Europe and Asia. Between 15–70% of reported cases are fatal. There is no approved vaccine available, and preclinical protection in vivo by an experimental vaccine has not been demonstrated previously. In the present study, the attenuated poxvirus vector, Modified Vaccinia virus Ankara, was used to develop a recombinant candidate vaccine expressing the CCHF virus glycoproteins. Cellular and humoral immunogenicity was confirmed in two mouse strains, including type I interferon receptor knockout mice, which are susceptible to CCHF disease. This vaccine protected all recipient animals from lethal disease in a challenge model adapted to represent infection via a tick bite. Histopathology and viral load analysis of protected animals confirmed that they had been exposed to challenge virus, even though they did not exhibit clinical signs. This is the first demonstration of efficacy of a CCHF vaccine.
has issue date	2014-03-12(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0091516
bibo:pmid	24621656
has license	cc-by
sha1sum (hex)	832fab67c299fb2682948d33858e58a5db71e6f8
schema:url	https://doi.org/10.1371/journal.pone.0091516
resource representing a document's title	A Novel Vaccine against Crimean-Congo Haemorrhagic Fever Protects 100% of Animals against Lethal Challenge in a Mouse Model
has PubMed Central identifier	PMC3951450
has PubMed identifier	24621656
schema:publication	PLoS One
resource representing a document's body	covid:832fab67c299fb2682948d33858e58a5db71e6f8#body_text
is schema:about of	named entity 'susceptible' named entity 'vaccine' named entity 'vaccine' named entity 'animals' named entity 'exposed' named entity 'Novel' named entity 'Animals' covid:arg/832fab67c299fb2682948d33858e58a5db71e6f8 named entity 'Africa' named entity 'virus' named entity 'Crimean-Congo Haemorrhagic Fever' named entity 'vaccine' named entity 'Middle East' named entity 'fatal' named entity 'model' named entity 'severe' named entity 'tick bite' named entity 'Modified' named entity 'vaccine' named entity 'CCHF' named entity 'CCHF' named entity 'mouse strains' named entity 'poxvirus' named entity 'Histopathology' named entity 'humoral' named entity 'Virus entry' named entity 'Sigma-Aldrich' named entity 'antigen' named entity 'cell-mediated' named entity 'milk protein' named entity 'protein' named entity 'CCHFv' named entity 'CCHFv' named entity 'body temperature' named entity 'liver' named entity 'vaccines' named entity 'Immunocompromised' named entity 'T-cell' named entity 'Nucleotides' named entity 'expression patterns' named entity 'macrophages' named entity 'PVDF' named entity 'viral RNA' named entity 'red blood cells' named entity 'antibody' named entity 'cytopathic effects' named entity 'pestle and mortar' named entity 'untranslated regions' named entity 'Porton Down' named entity 'antibody' named entity 'spleen' named entity 'polyclonal antibody' named entity 'Netherlands' named entity 'CCHFv' named entity 'spleen' named entity 'hepatocytes' named entity 'Life Technologies' named entity 'Red Blood Cell' named entity 'spleen' named entity 'peptide' named entity 'Animals (Scientific Procedures) Act 1986' named entity 'C57Bl/6' named entity 'IFN' named entity 'CCHFv' named entity 'protein' named entity 'Protective antibodies' named entity 'genomic DNA' named entity 'leader sequence' named entity 'immunodetection' named entity 'centrifugation' named entity 'stained with haematoxylin and eosin' named entity 'CCHF' named entity 'peptides' named entity 'immunised' named entity 'University of Leeds' named entity 'liver' named entity 'histology'

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