About: Saliva as a non-invasive sample for the detection of SARS-CoV-2: a systematic review

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About: Saliva as a non-invasive sample for the detection of SARS-CoV-2: a systematic review Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Saliva as a non-invasive sample for the detection of SARS-CoV-2: a systematic review
Creator	Khurshid, Zohaib Moin, Syed Speicher, David Joshi, Chaitanya Sohail Zafar, Muhammad Zohaib, Sana
Source	MedRxiv
abstract	The accepted gold standard for diagnosing coronavirus disease (COVID-19) is the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA from nasopharyngeal swabs (NPS). However, shortage of reagents has made NPS collection challenging, and alternative samples need to be explored. Due to its non-invasive nature, saliva has considerable diagnostic potential. Therefore, to guide diagnostic laboratories globally, we conducted a systematic review to determine the utility of saliva for the detection of SARS-CoV-2. A systematic search of major databases (PubMed, ISI Web of Science, Scopus, and Google Scholar) was performed to identify published studies in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. There was a total of 10 publications that fit the criteria for review. Most studies collected drooled whole saliva from hospitalized patients or pipetted saliva from intubated patients. Saliva was positive in 31-92% of patients depending on the cohort and length of hospitalization. Viral loads in saliva are comparable to those in NPS and ranged from 9.9 x 10^2 to 1.2 x 10^8 copies/mL during the first week of symptoms and decrease over time. Saliva can be positive up to 20 days post-symptom onset with viral loads correlating with symptom severity and degree of tissue damage. Based on these findings, we made suggestions to guide the clinical laboratory and suggest the need for diagnostic accuracy studies for the detection of SARS-CoV-2 from saliva.
has issue date	2020-05-13(xsd:dateTime)
bibo:doi	10.1101/2020.05.09.20096354
has license	medrxiv
sha1sum (hex)	82fff12162074c85970f58277accf679cf261344
schema:url	https://doi.org/10.1101/2020.05.09.20096354
resource representing a document's title	Saliva as a non-invasive sample for the detection of SARS-CoV-2: a systematic review
resource representing a document's body	covid:82fff12162074c85970f58277accf679cf261344#body_text
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