About: Immunogenicity of the spike glycoprotein of Bat SARS-like coronavirus

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About: Immunogenicity of the spike glycoprotein of Bat SARS-like coronavirus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Immunogenicity of the spike glycoprotein of Bat SARS-like coronavirus
Creator	Peng, Cheng Shi, Zheng-Li Zhou, Peng Chen, Ji-Guo Han, Zheng-Gang Hou, Yu-Xuan
source	Medline; PMC
abstract	A group of SARS-like coronaviruses (SL-CoV) have been identified in horseshoe bats. Despite SL-CoVs and SARS-CoV share identical genome structure and high-level sequence similarity, SL-CoV does not bind to the same cellular receptor as for SARS-CoV and the N-terminus of the S proteins only share 64% amino acid identity, suggesting there are fundamental differences between these two groups of coronaviruses. To gain insight into the basis of this difference, we established a recombinant adenovirus system expressing the S protein from SL-CoV (rAd-Rp3-S) to investigate its immune characterization. Our results showed that immunized mice generated strong humoral immune responses against the SL-CoV S protein. Moreover, a strong cellular immune response demonstrated by elevated IFN-γ and IL-6 levels was also observed in these mice. However, the induced antibody from these mice had weaker cross-reaction with the SARS-CoV S protein, and did not neutralize HIV pseudotyped with SARS-CoV S protein. These results demonstrated that the immunogenicity of the SL-CoV S protein is distinct from that of SARS-CoV, which may cause the immunological differences between human SARS-CoV and bat SL-CoV. Furthermore, the recombinant virus could serve as a potential vaccine candidate against bat SL-CoV infection.
has issue date	2010-02-12(xsd:dateTime)
bibo:doi	10.1007/s12250-010-3096-2
bibo:pmid	20960282
has license	no-cc
sha1sum (hex)	82c629c5878c63023651e3d44f00885525ecdae8
schema:url	https://doi.org/10.1007/s12250-010-3096-2
resource representing a document's title	Immunogenicity of the spike glycoprotein of Bat SARS-like coronavirus
has PubMed Central identifier	PMC7090579
has PubMed identifier	20960282
schema:publication	Virol Sin
resource representing a document's body	covid:82c629c5878c63023651e3d44f00885525ecdae8#body_text
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