About: Severely ill COVID-19 patients display augmented functional properties in SARS-CoV-2-reactive CD8(+) T cells

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About: Severely ill COVID-19 patients display augmented functional properties in SARS-CoV-2-reactive CD8(+) T cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Severely ill COVID-19 patients display augmented functional properties in SARS-CoV-2-reactive CD8(+) T cells
Creator	Kusnadi1, Anthony
Source	BioRxiv; Medline; PMC
abstract	The molecular properties of CD8(+) T cells that respond to SARS-CoV-2 infection are not fully known. Here, we report on the single-cell transcriptomes of >80,000 virus-reactive CD8(+) T cells from 39 COVID-19 patients and 10 healthy subjects. COVID-19 patients segregated into two groups based on whether the dominant CD8(+) T cell response to SARS-CoV-2 was ‘exhausted’ or not. SARS-CoV-2-reactive cells in the exhausted subset were increased in frequency and displayed lesser cytotoxicity and inflammatory features in COVID-19 patients with mild compared to severe illness. In contrast, SARS-CoV-2-reactive cells in the non-exhausted subsets from patients with severe disease showed enrichment of transcripts linked to co-stimulation, pro-survival NF-κB signaling, and anti-apoptotic pathways, suggesting the generation of robust CD8(+) T cell memory responses in patients with severe COVID-19 illness. CD8(+) T cells reactive to influenza and respiratory syncytial virus from healthy subjects displayed polyfunctional features. Cells with such features were mostly absent in SARS-CoV-2 responsive cells from both COVID-19 patients and healthy controls non-exposed to SARS-CoV-2. Overall, our single-cell analysis revealed substantial diversity in the nature of CD8(+) T cells responding to SARS-CoV-2.
has issue date	2020-07-10(xsd:dateTime)
bibo:doi	10.1101/2020.07.09.194027
bibo:pmid	32676602
has license	cc-by-nc-nd
sha1sum (hex)	82b551f082165627a8b7e340cc0ae1dce271d852
schema:url	https://doi.org/10.1101/2020.07.09.194027
resource representing a document's title	Severely ill COVID-19 patients display augmented functional properties in SARS-CoV-2-reactive CD8(+) T cells
has PubMed Central identifier	PMC7359524
has PubMed identifier	32676602
schema:publication	bioRxiv
resource representing a document's body	covid:82b551f082165627a8b7e340cc0ae1dce271d852#body_text
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