About: Cyclooxygenase activity is important for efficient replication of mouse hepatitis virus at an early stage of infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cyclooxygenase activity is important for efficient replication of mouse hepatitis virus at an early stage of infection
Creator	Raaben, Matthijs Bouma, Janneke Am De Haan, Cornelis Büller, Hans Raatgeep, Rolien Taminiau, Lucas Van Houdt, Michel Wa Rossen, John Wc Einerhand, Alexandra
Source	Medline; PMC
abstract	Cyclooxygenases (COXs) play a significant role in many different viral infections with respect to replication and pathogenesis. Here we investigated the role of COXs in the mouse hepatitis coronavirus (MHV) infection cycle. Blocking COX activity by different inhibitors or by RNA interference affected MHV infection in different cells. The COX inhibitors reduced MHV infection at a post-binding step, but early in the replication cycle. Both viral RNA and viral protein synthesis were affected with subsequent loss of progeny virus production. Thus, COX activity appears to be required for efficient MHV replication, providing a potential target for anti-coronaviral therapy.
has issue date	2007-06-07(xsd:dateTime)
bibo:doi	10.1186/1743-422x-4-55
bibo:pmid	17555580
has license	cc-by
sha1sum (hex)	82946d26f79e85f1b37f6fd965dc1d8a2ceb0c4d
schema:url	https://doi.org/10.1186/1743-422x-4-55
resource representing a document's title	Cyclooxygenase activity is important for efficient replication of mouse hepatitis virus at an early stage of infection
has PubMed Central identifier	PMC1892777
has PubMed identifier	17555580
schema:publication	Virol J
resource representing a document's body	covid:82946d26f79e85f1b37f6fd965dc1d8a2ceb0c4d#body_text
is schema:about of	named entity 'target' named entity 'investigated' named entity 'pathogenesis' named entity 'activity' covid:arg/82946d26f79e85f1b37f6fd965dc1d8a2ceb0c4d named entity 'MHV' named entity 'activity' named entity 'Both' named entity 'COXs' named entity 'protein synthesis' named entity 'subsequent' named entity 'COXs' named entity 'COX' named entity 'replication' named entity 'COX inhibitors' named entity 'protein synthesis' named entity 'virus' named entity 'pathogenesis' named entity 'mouse hepatitis virus' named entity 'reagent' named entity 'mRNA' named entity 'cell lysates' named entity 'SARS' named entity 'human cytomegalovirus' named entity 'infection' named entity 'HeLa' named entity 'RNA synthesis' named entity 'human immunodeficiency virus' named entity 'cytokine' named entity 'intracellular' named entity 'polyclonal' named entity 'NS-398' named entity 'COX-1 and COX-2' named entity 'assay' named entity 'viral infection' named entity 'inoculation' named entity 'protein' named entity 'transfected' named entity 'HCoV-HKU1' named entity 'pathogenesis' named entity 'viral protein' named entity 'bovine leukemia virus' named entity 'canine coronavirus' named entity 'dose-dependent manner' named entity 'RNA viruses' named entity 'cell types' named entity 'indomethacin' named entity 'mRNA' named entity 'indomethacin' named entity 'PCR' named entity 'COX-2' named entity 'inflammatory reaction' named entity '0.01' named entity 'Luciferase' named entity 'RT-PCR' named entity 'RNA' named entity 'taqman' named entity 'infection' named entity '10 nM' named entity 'COX inhibitors' named entity 'cellular immunity' named entity 'macrophages' named entity 'RNA synthesis' named entity 'COX inhibitors' named entity 'viral particles' named entity 'indomethacin' named entity 'COX-2' named entity 'replication cycle' named entity 'macrophages' named entity 'serum' named entity 'proinflammatory' named entity 'siRNAs' named entity 'Western blotting'

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