About: Long noncoding RNAs (lncRNAs) dynamics evidence immunomodulation during ISAV-Infected Atlantic salmon (Salmo salar)

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About: Long noncoding RNAs (lncRNAs) dynamics evidence immunomodulation during ISAV-Infected Atlantic salmon (Salmo salar) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Long noncoding RNAs (lncRNAs) dynamics evidence immunomodulation during ISAV-Infected Atlantic salmon (Salmo salar)
Creator	Aguilar, Andrea Boltaña, Sebastian Gallardo-Escárate, Cristian Mackenzie, Simon Valenzuela-Miranda, Diego
Source	Medline; PMC
abstract	Despite evidence for participation in the host response to infection, the roles of many long non-coding RNAs (lncRNAs) remain unknown. Therefore, the aims of this study were to identify lncRNAs in Atlantic salmon (Salmo salar) and evaluate their transcriptomic regulation during ISA virus (ISAV) infection, an Orthomyxoviridae virus associated with high mortalities in salmonid aquaculture. Using next-generation sequencing, whole-transcriptome analysis of the Salmo salar response to ISAV infection was performed, identifying 5,636 putative lncRNAs with a mean length of 695 base pairs. The transcriptional modulation evidenced a similar number of differentially expressed lncRNAs in the gills (3,294), head-kidney (3,275), and liver (3,325) over the course of the infection. Moreover, analysis of a subset of these lncRNAs showed the following: (i) Most were similarly regulated in response to ISA virus infection; (ii) The transcript subsets were uniquely modulated in each tissue (gills, liver, and head-kidney); and (iii) A subset of lncRNAs were upregulated for each tissue and time analysed, indicating potential markers for ISAV infection. These findings represent the first discovery of widespread differential expression of lncRNAs in response to virus infection in non-model species, suggesting that lncRNAs could be involved in regulating the host response during ISAV infection.
has issue date	2016-03-04(xsd:dateTime)
bibo:doi	10.1038/srep22698
bibo:pmid	26939752
has license	cc-by
sha1sum (hex)	8213f353876b2eba6110eae70dae057a2f08b93f
schema:url	https://doi.org/10.1038/srep22698
resource representing a document's title	Long noncoding RNAs (lncRNAs) dynamics evidence immunomodulation during ISAV-Infected Atlantic salmon (Salmo salar)
has PubMed Central identifier	PMC4778034
has PubMed identifier	26939752
schema:publication	Sci Rep
resource representing a document's body	covid:8213f353876b2eba6110eae70dae057a2f08b93f#body_text
is schema:about of	named entity '283' named entity 'MODULATION' named entity 'FINDINGS' named entity 'INVOLVED' named entity 'SALMONID' named entity 'USING' named entity 'DISCOVERY' named entity 'POTENTIAL' named entity 'ANALYSIS' named entity 'VIRUS ASSOCIATED' named entity 'REGULATED' named entity 'LONG NON-CODING RNAS' named entity 'TIME' named entity 'TRANSCRIPTOME ANALYSIS' named entity 'MODULATED' named entity 'ATLANTIC SALMON' named entity 'MORTALITIES' named entity 'HIGH' named entity 'VIRUS' named entity 'BASE PAIRS' named entity 'COULD BE' named entity 'MODEL' named entity 'PARTICIPATION' named entity 'SUBSET' named entity 'EXPRESSED' named entity 'REPRESENT' named entity 'VIRUS INFECTION' named entity 'ISAV' named entity 'ORTHOMYXOVIRIDAE' named entity 'host response' named entity 'performed' named entity 'OPEN' named entity 'Salmo salar' named entity 'TO IDENTIFY' named entity 'EVIDENCE FOR' named entity 'NUMBER OF' named entity 'DIFFERENTIAL EXPRESSION' named entity 'TRANSCRIPT' named entity 'SPECIES' named entity 'COURSE' named entity 'AQUACULTURE' named entity 'REGULATION' named entity 'TISSUE' named entity 'MEAN' named entity 'PERFORMED' named entity 'NEXT-GENERATION SEQUENCING' named entity 'HEAD' named entity 'WIDESPREAD' named entity 'ASSOCIATED WITH' named entity 'MARKERS' named entity 'THESE' named entity 'STUDY' named entity 'GILLS' named entity 'ATLANTIC SALMON' named entity 'ISAV' named entity 'SALAR' named entity 'IMMUNOMODULATION' named entity 'INFECTED' named entity 'RNAS' named entity 'EVIDENCE' named entity 'DYNAMICS' named entity 'LONG' named entity 'OPEN' named entity 'ISA' named entity 'KIDNEY' named entity 'IDENTIFYING' named entity 'EVALUATE' named entity 'INFECTION' named entity 'THEIR' named entity 'UNKNOWN' named entity 'LIVER' named entity 'INDICATING' named entity 'SIMILAR' named entity 'RESPONSE TO VIRUS' named entity 'UPREGULATED' named entity 'SALMO SALAR' named entity 'NON-'

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