About: Signatures of malaria-associated pathology revealed by high-resolution whole-blood transcriptomics in a rodent model of malaria

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About: Signatures of malaria-associated pathology revealed by high-resolution whole-blood transcriptomics in a rodent model of malaria Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Signatures of malaria-associated pathology revealed by high-resolution whole-blood transcriptomics in a rodent model of malaria
Creator	Langhorne, Jean Lamb, Tracey Cunningham, Deirdre Deroost, Katrien Graham, Christine Hosking, Caroline Janse, Chris Ramesar, Jai Sodenkamp, Jan Spencer-Dene, Bradley Tshitenge, Tshibuayi O'garra, Anne Lin, Jing-Wen Mclaughlin, Sarah
Source	Medline; PMC
abstract	The influence of parasite genetic factors on immune responses and development of severe pathology of malaria is largely unknown. In this study, we performed genome-wide transcriptomic profiling of mouse whole blood during blood-stage infections of two strains of the rodent malaria parasite Plasmodium chabaudi that differ in virulence. We identified several transcriptomic signatures associated with the virulent infection, including signatures for platelet aggregation, stronger and prolonged anemia and lung inflammation. The first two signatures were detected prior to pathology. The anemia signature indicated deregulation of host erythropoiesis, and the lung inflammation signature was linked to increased neutrophil infiltration, more cell death and greater parasite sequestration in the lungs. This comparative whole-blood transcriptomics profiling of virulent and avirulent malaria shows the validity of this approach to inform severity of the infection and provide insight into pathogenic mechanisms.
has issue date	2017-02-03(xsd:dateTime)
bibo:doi	10.1038/srep41722
bibo:pmid	28155887
has license	cc-by
sha1sum (hex)	81f6d476d70cdce38efdd5e0448e565d78f4b85c
schema:url	https://doi.org/10.1038/srep41722
resource representing a document's title	Signatures of malaria-associated pathology revealed by high-resolution whole-blood transcriptomics in a rodent model of malaria
has PubMed Central identifier	PMC5290525
has PubMed identifier	28155887
schema:publication	Sci Rep
resource representing a document's body	covid:81f6d476d70cdce38efdd5e0448e565d78f4b85c#body_text
is schema:about of	named entity 'stronger' named entity 'transcriptomics' covid:arg/81f6d476d70cdce38efdd5e0448e565d78f4b85c named entity 'Plasmodium' named entity 'pathology' named entity 'neutrophil' named entity 'anemia' named entity 'transcriptomic' named entity 'identified' named entity 'comparative' named entity 'host' named entity 'provide' named entity 'cell death' named entity 'signature' named entity 'immune responses' named entity 'signature' named entity 'platelet aggregation' named entity 'malaria' named entity 'infection' named entity 'virulence' named entity 'infection' named entity 'immune responses' named entity 'virulent' named entity 'neutrophil' named entity 'lung inflammation' named entity 'rodent' named entity 'malaria' named entity 'malaria' named entity 'IgM' named entity 'lungs' named entity 'clustering algorithm' named entity 'epithelial' named entity 'genetic diversity' named entity 'luciferase' named entity 'up-regulated' named entity 'hybridized' named entity 'perfusion' named entity 'SOM' named entity 'malaria' named entity 'perfused' named entity 'mice' named entity 'Flow cytometry' named entity 'mice' named entity 'mice' named entity 'transcriptomic' named entity 'Merck Millipore' named entity 'Leica' named entity 'mice' named entity 'pathology' named entity 'Euclidean distance' named entity 'infection' named entity 'anemia' named entity 'mice' named entity 'tracheal' named entity 'C57BL/6' named entity 'macrophage' named entity 'Thermo Scientific' named entity 'parasites' named entity 'perfused' named entity 'mice' named entity 'red blood cells' named entity 'immunology' named entity 'transcriptome' named entity 'staining' named entity 'Histology' named entity 'RBC' named entity 'chromosomes' named entity 'lung inflammation'

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