About: Immunological evaluation of invasive Lactobacillus plantarum co-expressing EtMIC2 and chicken interleukin-18 against Eimeria tenella

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About: Immunological evaluation of invasive Lactobacillus plantarum co-expressing EtMIC2 and chicken interleukin-18 against Eimeria tenella Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immunological evaluation of invasive Lactobacillus plantarum co-expressing EtMIC2 and chicken interleukin-18 against Eimeria tenella
Creator	Liu, Jing Liu, Yang Gao, Xing Wang, Dan Huang, Hai-Bin Jiang, Yan-Long Kang, Yuan-Huan Shi, Chun-Wei Wang, Chun-Feng Wang, Jian-Zhong Yang, Gui-Lian Yang, Wen-Tao Zhang, Zan
Source	PMC
abstract	Chicken coccidiosis is a protozoan parasitic disease that leads to considerable economic losses in the poultry industry. In this study, we used invasive Lactobacillus plantarum (L.P) expressing the FnBPA protein as a novel bacterial carrier for DNA delivery into epithelial cells to develop a live oral DNA vaccine. A fusion DNA vaccine co-expressing EtMIC2 and chicken IL-18 (chIL-18) was constructed and then delivered to the host by invasive L.P. Its efficacy against Eimeria tenella challenge was evaluated in chickens by examining the relative weight gain rate; caecal lesion score; OPG; anti-coccidial index (ACI); levels of EtMIC2 antibody, FnBPA, IL-4, IL-18, IFN-γ and SIgA; and proliferation ability and percentages of CD4(+) and CD8(+) splenocytes. The experimental results showed that chickens immunized with invasive L.P carrying the eukaryotic expression vector pValac-EtMIC2 (pValac-EtMIC2/pSIP409-FnBPA) had markedly improved immune protection against challenge compared with that of chickens immunized with non-invasive L.P (pValac-EtMIC2/pSIP409). However, invasive L.P co-expressing EtMIC2 with the chIL-18 vector exhibited the highest protection efficiency against E. tenella. These results indicate that invasive Lactobacillus-expressing FnBPA improved humoural and cellular immunity and enhanced resistance to E. tenella. The DNA vaccine delivered by invasive Lactobacillus provides a new concept and method for the prevention of E. tenella.
has issue date	2020-07-27(xsd:dateTime)
bibo:doi	10.1007/s00436-020-06745-w
has license	no-cc
sha1sum (hex)	81d67f2dec84c22e3e88f75389b07f9e89d67669
schema:url	https://doi.org/10.1007/s00436-020-06745-w
resource representing a document's title	Immunological evaluation of invasive Lactobacillus plantarum co-expressing EtMIC2 and chicken interleukin-18 against Eimeria tenella
has PubMed Central identifier	PMC7382971
schema:publication	Parasitol Res
resource representing a document's body	covid:81d67f2dec84c22e3e88f75389b07f9e89d67669#body_text
is schema:about of	named entity 'ECONOMIC' named entity 'RESISTANCE TO' named entity 'LACTOBACILLUS' named entity 'HOST' named entity 'IMPROVED' named entity 'CHICKENS' named entity 'EVALUATED' named entity 'PREVENTION OF' named entity 'EPITHELIAL CELLS' named entity 'FNBPA' named entity 'chicken' named entity 'experimental group' named entity 'trypsin' named entity 'Lactobacillus' named entity 'weight gain' named entity 'epithelial cells' named entity 'CD8 +' named entity 'protozoan' named entity 'CD4 +' named entity 'Chicken' named entity 'DNA vaccine' named entity 'DNA vaccine' named entity 'IL-18' named entity 'IL-4' named entity 'eukaryotic' named entity 'Lactobacillus plantarum' named entity 'Lactobacillus' named entity 'chicken' named entity 'reagent' named entity 'vector' named entity 'plasmids' named entity 'DAPI' named entity 'H&E' named entity 'gfp' named entity 'coccidiosis' named entity '293T cells' named entity 'exogenous' named entity 'coccidiosis' named entity 'caecum' named entity 'pathogenicity' named entity 'Lactobacillus' named entity 'IL-4' named entity 'LAB' named entity 'China' named entity 'parasitic' named entity 'IL-2' named entity 'DNA vaccine' named entity 'inflammatory responses' named entity 'cell surface' named entity 'Cytokines' named entity 'caecal' named entity 'ability to invade' named entity 'transfected' named entity 'whey protein' named entity 'IL-18' named entity 'plasmids' named entity 'Invitrogen' named entity 'centrifuged' named entity 'vectors' named entity 'IFN-γ' named entity 'CD8 +' named entity 'microneme' named entity 'caecal' named entity 'protein' named entity 'gene' named entity 'competent cells' named entity '8 days' named entity 'monoclonal antibodies' named entity 'CD3' named entity 'fibronectin' named entity 'protein'

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