About: Statistical Methods for Processing Neuroimaging Data from Two Different Sites with a Down Syndrome Population Application

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Statistical Methods for Processing Neuroimaging Data from Two Different Sites with a Down Syndrome Population Application
Creator	Muschelli, John Christian, Bradley Cohen, Ann Crainiceanu, Ciprian Handen, Benjamin Johnson, Sterling Klunk, William Laymon, Charles Mathis, Chester Mettenburg, Joseph Minhas, Davneet Tudorascu, Dana Yang, Zixi Zammit, Matthew
Source	PMC
abstract	Harmonization of magnetic resonance imaging (MRI) and positron emission tomography (PET) scans from multi-scanner and multi-site studies presents a challenging problem. We applied the Removal of Artificial Voxel Effect by Linear regression (RAVEL) method to normalize T1-MRI intensities collected on two different scanners across two different sites as part of the Neurodegeneration in Aging Down syndrome (NiAD) study. The effects on FreeSurfer regional cortical thickness and volume outcome measures, in addition to FreeSurfer-based regional quantification of amyloid PET standardized uptake value ratio (SUVR) outcomes, were evaluated. A neuroradiologist visually assessed the accuracy of FreeSurfer hippocampus segmentations with and without the application of RAVEL. Quantitative results demonstrated that the application of RAVEL intensity normalization prior to running FreeSurfer significantly impacted both FreeSurfer volume and cortical thickness outcome measures. Visual assessment demonstrated that the application of RAVEL significantly improved FreeSurfer hippocampal segmentation accuracy. The RAVEL intensity normalization had little impact on PET SUVR measures.
has issue date	2020-05-16(xsd:dateTime)
bibo:doi	10.1007/978-3-030-50153-2_28
has license	no-cc
sha1sum (hex)	81b116d48b9b4f5353f6980801a6dbe6ab114ebb
schema:url	https://doi.org/10.1007/978-3-030-50153-2_28
resource representing a document's title	Statistical Methods for Processing Neuroimaging Data from Two Different Sites with a Down Syndrome Population Application
has PubMed Central identifier	PMC7274647
schema:publication	Information Processing and Management of Uncertainty in Knowledge-Based Systems
resource representing a document's body	covid:81b116d48b9b4f5353f6980801a6dbe6ab114ebb#body_text
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