About: Sialic acid involves in the interaction between ovomucin and hemagglutinin and influences the antiviral activity of ovomucin

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About: Sialic acid involves in the interaction between ovomucin and hemagglutinin and influences the antiviral activity of ovomucin Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Sialic acid involves in the interaction between ovomucin and hemagglutinin and influences the antiviral activity of ovomucin
Creator	Wang, Ning Xu, Qi Liu, Yaping Ma, Meihu Shan, Yuanyuan Zhang, Maojie
topic	covid:816a01fd2fcf6fdb0123f9404fbf2bdaac23f537#this
Source	Elsevier; Medline; PMC
abstract	Abstract Ovomucin (OVM) plays an important role in inhibiting infection of various pathogens. However, this bioactivity mechanism is not much known. Here, the role of sialic acid in OVM anti-virus activity has been studied by ELISA with lectin or ligand. Structural changes of OVM after removing sialic acid were analyzed by circular dichroism and fluorescence spectroscopy. OVM could be binding to the hemagglutinin (HA) of avian influenza viruses H5N1 and H1N1, this binding was specific and required the involvement of sialic acid. When sialic acid was removed, the binding was significantly reduced 71.5% and 64.35%, respectively. Therefore, sialic acid was proved as a recognition site which avian influenza virus bound to. Meanwhile, the endogenous fluorescence and surface hydrophobicity of OVM removing sialic acid were increased and the secondary structure tended to shift to random coil. This indicated that OVM molecules were in an unfolded state and spatial conformation disorder raising weakly. Remarkably, free sialic acid strongly promoted OVM binding to HA and thereby enhanced the interaction. It may contribute to the inhibition of host cell infection, agglutinate viruses. This study can be extended to the deepening of passive immunization field.
has issue date	2018-11-30(xsd:dateTime)
bibo:doi	10.1016/j.ijbiomac.2018.07.186
bibo:pmid	30071221
has license	els-covid
sha1sum (hex)	816a01fd2fcf6fdb0123f9404fbf2bdaac23f537
schema:url	https://doi.org/10.1016/j.ijbiomac.2018.07.186
resource representing a document's title	Sialic acid involves in the interaction between ovomucin and hemagglutinin and influences the antiviral activity of ovomucin
has PubMed Central identifier	PMC7124660
has PubMed identifier	30071221
schema:publication	International Journal of Biological Macromolecules
resource representing a document's body	covid:816a01fd2fcf6fdb0123f9404fbf2bdaac23f537#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/816a01fd2fcf6fdb0123f9404fbf2bdaac23f537
is schema:about of	named entity 'CONTRIBUTE ' named entity 'ANALYZED' named entity 'REDUCED' named entity 'SIALIC ACID' named entity 'INCREASED' named entity 'BOUND' named entity 'AVIAN INFLUENZA' named entity 'UNFOLDED STATE' named entity 'ROLE' named entity 'DISORDER' named entity 'VIRUSES' named entity 'REQUIRED' named entity 'INDICATED' named entity 'SITE' named entity 'VIRUS' named entity 'FREE' named entity 'IMPORTANT' named entity 'recognition site' named entity 'studied' named entity 'Structural' named entity 'acid' named entity 'influences' named entity 'HEMAGGLUTININ' covid:arg/816a01fd2fcf6fdb0123f9404fbf2bdaac23f537 named entity 'INTERACTION' named entity 'HOST CELL' named entity 'ANTIVIRAL ACTIVITY' named entity 'SIALIC ACID' named entity 'RECOGNITION' named entity 'CIRCULAR DICHROISM' named entity 'AVIAN INFLUENZA VIRUS' named entity 'REMOVED' named entity 'HERE' named entity 'CHANGES' named entity 'OVOMUCIN' named entity 'OVM' named entity 'RANDOM COIL' named entity 'BIOACTIVITY' named entity 'MOLECULES' named entity 'H 1' named entity 'VARIOUS' named entity 'MECHANISM' named entity 'SPATIAL' named entity 'KNOWN' named entity 'LIGAND' named entity 'PLAYS' named entity 'EXTENDED' named entity 'STUDY' named entity 'TO SHIFT' named entity 'HEMAGGLUTININ' named entity 'OVOMUCIN' named entity 'COULD BE' named entity 'INFLUENZA VIRUSES' named entity 'INHIBITION' named entity 'FIELD' named entity 'INTERACTION' named entity 'MUCH' named entity 'SPECIFIC' named entity 'REMOVING' named entity 'INVOLVEMENT' named entity 'BINDING' named entity 'ACTIVITY' named entity 'INHIBITING' named entity 'DEEPENING' named entity 'SECONDARY STRUCTURE' named entity 'HYDROPHOBICITY' named entity 'ENDOGENOUS FLUORESCENCE' named entity 'CONFORMATION' named entity 'STRUCTURAL' named entity 'FLUORESCENCE SPECTROSCOPY' named entity 'LECTIN' named entity 'SURFACE' named entity 'PATHOGENS' named entity 'PASSIVE IMMUNIZATION'

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