About: Lissencephaly in Shih Tzu dogs

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Lissencephaly in Shih Tzu dogs
Creator	Amorim, Rogério Boff, Giovana Fernando Thomé, Edval Maria De Vasconcelos Machado, Vânia Noé Rodríguez-Sánchez, Diego Pinto, Araujo
Source	PMC
abstract	BACKGROUND: Lissencephaly is a brain malformation characterized by smooth and thickened cerebral surface, which may result in structural epilepsy. Lissencephaly is not common in veterinary medicine. Here, we characterize the first cases of lissencephaly in four Shih Tzu dogs, including clinical presentations and findings of magnetic resonance imaging of lissencephaly and several concomitant brain malformations. CASE PRESENTATION: Early-onset acute signs of forebrain abnormalities were observed in all dogs, which were mainly cluster seizures and behavioral alterations. Based on neurological examination, the findings were consistent with symmetrical and bilateral forebrain lesions. Metabolic disorders and inflammatory diseases were excluded. Magnetic resonance imaging for three dogs showed diffuse neocortical agyria and thickened gray matter while one dog had mixed agyria and pachygyria. Other features, such as internal hydrocephalus, supracollicular fluid accumulation, and corpus callosum hypoplasia, were detected concomitantly. Antiepileptic drugs effectively controlled cluster seizures, however, sporadic isolated seizures and signs of forebrain abnormalities, such as behavioral alterations, central blindness, and strabismus persisted. CONCLUSIONS: Lissencephaly should be considered an important differential diagnosis in Shih Tzu dogs presenting with early-onset signs of forebrain abnormalities, including cluster seizures and behavioral alterations. Magnetic resonance imaging was appropriate for ante-mortem diagnosis of lissencephaly and associated cerebral anomalies.
has issue date	2020-06-20(xsd:dateTime)
bibo:doi	10.1186/s13028-020-00528-0
bibo:pmid	32563254
has license	cc-by
sha1sum (hex)	8166e63ed2ffd5144dc6ab9c755c6f6153dc3cd3
schema:url	https://doi.org/10.1186/s13028-020-00528-0
resource representing a document's title	Lissencephaly in Shih Tzu dogs
has PubMed Central identifier	PMC7305484
has PubMed identifier	32563254
schema:publication	Acta Vet Scand
resource representing a document's body	covid:8166e63ed2ffd5144dc6ab9c755c6f6153dc3cd3#body_text
is schema:about of	named entity 'malformation' named entity 'Lissencephaly' named entity 'MAGNETIC RESONANCE IMAGING' named entity 'lissencephaly' named entity 'cases' named entity 'Shih Tzu' named entity 'Lissencephaly' named entity 'magnetic resonance imaging' named entity 'Lissencephaly' named entity 'strabismus' named entity 'seizures' named entity 'KBr' named entity 'sulci' named entity 'gyri' named entity 'seizures' named entity 'tonic-clonic seizures' named entity 'interictal' named entity 'seizures' named entity 'Hydrocephalus' named entity 'polyphagia' named entity 'serum' named entity 'histopathological' named entity 'PCR' named entity 'meningoencephalitis' named entity 'Genom' named entity 'PCR' named entity 'seizures' named entity 'Histopathology' named entity 'hydrocephalus' named entity 'clinical signs' named entity 'Italy' named entity 'Lissencephaly' named entity 'veterinarian' named entity 'hypoplasia' named entity 'CBC' named entity 'motor function' named entity 'SFA' named entity 'serum' named entity 'subcortical' named entity 'forebrain' named entity 'Cranial nerve examination' named entity 'phenobarbital' named entity 'seizures' named entity 'treatment modality' named entity 'canine distemper virus' named entity 'lesion' named entity 'lissencephaly' named entity 'rectum' named entity 'sulci' named entity 'lissencephaly' named entity 'urine' named entity 'Brazil' named entity 'lissencephaly' named entity 'motor areas' named entity 'phenobarbital' named entity 'lissencephaly' named entity 'cingulate gyrus' named entity 'lissencephaly' named entity 'sulci' named entity 'early-onset' named entity 'Brazil' named entity 'lissencephaly' named entity 'lissencephaly' named entity 'SFA' named entity 'polymicrogyria' named entity 'seizures' named entity 'strabismus' named entity 'antibody' named entity 'toy breed' named entity 'mice' named entity 'tubulin' named entity 'meningoencephalitis' named entity 'UNESP' named entity 'agyria' named entity 'intraventricular' named entity 'postictal stage'

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