About: The Importance of Mouse Models to Define Immunovirologic Determinants of Progressive Multifocal Leukoencephalopathy

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About: The Importance of Mouse Models to Define Immunovirologic Determinants of Progressive Multifocal Leukoencephalopathy Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Importance of Mouse Models to Define Immunovirologic Determinants of Progressive Multifocal Leukoencephalopathy
Creator	Frost, Elizabeth Lukacher, Aron Monson, Nancy Schwab, Nicholas
topic	covid:815b5e537a3e7bdb7d5c7c7cd51181b9b2e245c5#this
Source	Medline; PMC
abstract	Progressive multifocal leukoencephalopathy (PML) is a severely debilitating and often fatal demyelinating disease of the central nervous system (CNS) in immunosuppressed individuals caused by JC polyomavirus (JCV), a ubiquitous human pathogen. Demyelination results from lytically infected oligodendrocytes, whose clearance is impaired in the setting of depressed JCV-specific T cell-mediated CNS surveillance. Although mutations in the viral capsid and genomic rearrangements in the viral non-coding region appear to set the stage for PML in the immunosuppressed population, mechanisms of demyelination and CNS antiviral immunity are poorly understood in large part due to absence of a tractable animal model that mimics PML neuropathology in humans. Early studies using mouse polyomavirus (MPyV) in T cell-deficient mice demonstrated productive viral replication in the CNS and demyelination; however, these findings were confounded by spinal cord compression by virus-induced vertebral bone tumors. Here, we review current literature regarding animal models of PML, focusing on current trends in antiviral T cell immunity in non-lymphoid organs, including the CNS. Advances in our understanding of polyomavirus lifecycles, viral and host determinants of persistent infection, and T cell-mediated immunity to viral infections in the CNS warrant revisiting polyomavirus CNS infection in the mouse as a bona fide animal model for JCV-PML.
has issue date	2015-01-05(xsd:dateTime)
bibo:doi	10.3389/fimmu.2014.00646
bibo:pmid	25601860
has license	cc-by
sha1sum (hex)	815b5e537a3e7bdb7d5c7c7cd51181b9b2e245c5
schema:url	https://doi.org/10.3389/fimmu.2014.00646
resource representing a document's title	The Importance of Mouse Models to Define Immunovirologic Determinants of Progressive Multifocal Leukoencephalopathy
has PubMed Central identifier	PMC4283601
has PubMed identifier	25601860
schema:publication	Front Immunol
resource representing a document's body	covid:815b5e537a3e7bdb7d5c7c7cd51181b9b2e245c5#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/815b5e537a3e7bdb7d5c7c7cd51181b9b2e245c5
is schema:about of	named entity 'mutations' named entity 'organs' named entity 'spinal cord compression' named entity 'oligodendrocytes' named entity 'JCV' named entity 'determinants' named entity 'mouse' named entity 'NON-' named entity 'DEMYELINATION' named entity 'DEPRESSED' named entity 'IS A' named entity 'BONE TUMORS' named entity 'REARRANGEMENTS' named entity 'MOUSE POLYOMAVIRUS' named entity 'MIMICS' named entity 'INDUCED' named entity 'SURVEILLANCE' named entity 'FINDINGS' named entity 'HOST' named entity 'STUDIES' named entity 'HERE' named entity 'DETERMINANTS' named entity 'VIRAL' named entity 'SET' named entity 'CLEARANCE' named entity 'UBIQUITOUS' named entity 'STAGE' named entity 'INCLUDING' named entity 'VIRAL INFECTIONS' named entity 'T CELL IMMUNITY' named entity 'DEFICIENT' named entity 'ABSENCE OF' named entity 'DEMYELINATING DISEASE' named entity 'VIRAL REPLICATION' named entity 'EARLY' named entity 'IMPAIRED' named entity 'MEDIATED' named entity 'LARGE' named entity 'CELL-MEDIATED IMMUNITY' named entity 'PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY' named entity 'NEUROPATHOLOGY' named entity 'RESULTS' named entity 'MOUSE' named entity 'OLIGODENDROCYTES' named entity 'CURRENT' named entity 'VIRAL CAPSID' named entity 'PRODUCTIVE' named entity 'VERTEBRAL BONE' named entity 'DETERMINANTS' named entity 'UNDERSTANDING' named entity 'OUR' named entity 'LITERATURE' named entity 'POPULATION' named entity 'GENOMIC' named entity 'USING' named entity 'ANIMAL MODEL' named entity 'PML' named entity 'CNS' named entity 'MOUSE MODELS' named entity 'SEVERELY' named entity 'IMMUNITY' named entity 'PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY' named entity 'CNS INFECTION' named entity 'UNDERSTOOD' named entity 'SPECIFIC' named entity 'MICE' named entity 'IMMUNOSUPPRESSED' named entity 'APPEAR' named entity 'LYMPHOID ORGANS' named entity 'FOCUSING' named entity 'TRENDS' named entity 'DUE TO' named entity 'CODING REGION' named entity 'POORLY' named entity 'POLYOMAVIRUS' named entity 'ANTIVIRAL'

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