About: Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways

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About: Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways
Creator	Zheng, Bo-Jian Chan, Jasper Fuk-Woo Yuen, Kwok-Yung Wang, Dong Zhou, Jie Qin, Chuan Chu, Hin Yang, Dong Yeung, Man-Lung Li, Cun Yao, Yanfeng Cai, Jian-Piao Chan, Ivy Hau-Yee Cheng, Zhong-Shan Lee, To, Kai-Wang Wong, Yin Ho, Bosco Ho, Wai-Kuen Chak-Yiu, Andrew Li, Chuangen
topic	covid:8151dfc9e043b28e50d9e8614d11fa3768b50b79#this
Source	Medline; PMC
abstract	Middle East respiratory syndrome (MERS) is associated with a mortality rate of >35%. We previously showed that MERS coronavirus (MERS-CoV) could infect human macrophages and dendritic cells and induce cytokine dysregulation. Here, we further investigated the interplay between human primary T cells and MERS-CoV in disease pathogenesis. Importantly, our results suggested that MERS-CoV efficiently infected T cells from the peripheral blood and from human lymphoid organs, including the spleen and the tonsil. We further demonstrated that MERS-CoV infection induced apoptosis in T cells, which involved the activation of both the extrinsic and intrinsic apoptosis pathways. Remarkably, immunostaining of spleen sections from MERS-CoV–infected common marmosets demonstrated the presence of viral nucleoprotein in their CD3(+) T cells. Overall, our results suggested that the unusual capacity of MERS-CoV to infect T cells and induce apoptosis might partly contribute to the high pathogenicity of the virus.
has issue date	2016-03-15(xsd:dateTime)
bibo:doi	10.1093/infdis/jiv380
bibo:pmid	26203058
has license	no-cc
sha1sum (hex)	8151dfc9e043b28e50d9e8614d11fa3768b50b79
schema:url	https://doi.org/10.1093/infdis/jiv380
resource representing a document's title	Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways
has PubMed Central identifier	PMC7107330
has PubMed identifier	26203058
schema:publication	J Infect Dis
resource representing a document's body	covid:8151dfc9e043b28e50d9e8614d11fa3768b50b79#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/8151dfc9e043b28e50d9e8614d11fa3768b50b79
is schema:about of	named entity 'OUR' named entity 'CAPACITY' named entity 'MERS CORONAVIRUS' named entity 'INVOLVED' named entity 'DEMONSTRATED' named entity 'INFECTION INDUCED' named entity 'RESULTS' named entity 'DENDRITIC CELLS' named entity 'EXTRINSIC' named entity 'INDUCE' named entity 'CYTOKINE ' named entity 'PRESENCE OF' named entity 'T cells' named entity 'immunostaining' named entity 'infection' named entity 'Overall' named entity 'infected' named entity 'T Lymphocytes' named entity 'ACTIVATES' named entity 'T CELLS' named entity 'VIRUS' named entity 'ASSOCIATED WITH' named entity 'INTRINSIC APOPTOSIS' named entity 'JOURNAL ' named entity 'MIDDLE EAST RESPIRATORY SYNDROME ' named entity 'TONSIL' named entity 'CONTRIBUTE ' named entity 'LYMPHOID ORGANS' named entity 'MACROPHAGES' named entity 'PATHOGENESIS' named entity 'HERE' named entity 'CD3' named entity 'MERS-COV' named entity 'ACTIVATION' named entity 'T LYMPHOCYTES' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'INFECTS' named entity 'EXTRINSIC' named entity 'OVERALL' named entity 'UNUSUAL' named entity 'INCLUDING' named entity 'TO INFECT' named entity 'HIGH' named entity 'VIRAL' named entity 'PRIMARY' named entity 'HUMAN' named entity 'INFECTIOUS DISEASES' named entity 'PATHWAYS' named entity 'DISEASE' named entity 'INTRINSIC APOPTOSIS' named entity 'APOPTOSIS' named entity 'PERIPHERAL BLOOD' named entity 'MORTALITY RATE' named entity 'COMMON' named entity 'THEIR' named entity 'HUMAN' named entity 'INVESTIGATED' named entity 'INFECTED' named entity 'SPLEEN'

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