About: A Multiple Antigenic Peptide Mimicking Peptidoglycan Induced T Cell Responses to Protect Mice from Systemic Infection with Staphylococcus aureus

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: A Multiple Antigenic Peptide Mimicking Peptidoglycan Induced T Cell Responses to Protect Mice from Systemic Infection with Staphylococcus aureus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A Multiple Antigenic Peptide Mimicking Peptidoglycan Induced T Cell Responses to Protect Mice from Systemic Infection with Staphylococcus aureus
Creator	Zhu, Ping Lu, Xiao Chen, Yi-Guo Fu, Ning Huang, Zhao-Xia Liu, Bei-Yi Wang, Xiang-Yu Wen, Kun
Source	PMC
abstract	Due to the enormous capacity of Staphylococcus aureus to acquire antibiotic resistance, it becomes imperative to develop vaccines for decreasing the risk of its life-threatening infections. Peptidoglycan (PGN) is a conserved and major component of S. aureus cell wall. However, it has not been used as a vaccine candidate since it is a thymus-independent antigen. In this study, we synthesized a multiple antigenic peptide, named MAP27, which comprised four copies of a peptide that mimics the epitope of PGN. After immunization with MAP27 five times and boosting with heat-inactivated bacterium one time, anti-MAP27 serum bound directly to S. aureus or PGN. Immunization with MAP27 decreased the bacterial burden in organs of BALB/c mice and significantly prolonged their survival time after S. aureus lethal-challenge. The percentage of IFN-γ(+)CD3(+) T cells and IL-17(+)CD4(+) T cells in spleen, as well as the levels of IFN-γ, IL-17A/F and CCL3 in spleen and lung, significantly increased in the MAP27-immunized mice after infection. Moreover, in vitro incubation of heat-inactivated S. aureus with splenocytes isolated from MAP27-immunized mice stimulated the production of IFN-γ and IL-17A/F. Our findings demonstrated that MAP27, as a thymus-dependent antigen, is efficient at eliciting T cell-mediated responses to protect mice from S. aureus infection. This study sheds light on a possible strategy to design vaccines against S. aureus.
has issue date	2015-08-28(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0136888
bibo:pmid	26317210
has license	cc-by
sha1sum (hex)	8147b5b09a09887d1b4c4871d9d49746d8c4d418
schema:url	https://doi.org/10.1371/journal.pone.0136888
resource representing a document's title	A Multiple Antigenic Peptide Mimicking Peptidoglycan Induced T Cell Responses to Protect Mice from Systemic Infection with Staphylococcus aureus
has PubMed Central identifier	PMC4552945
has PubMed identifier	26317210
schema:publication	PLoS One
resource representing a document's body	covid:8147b5b09a09887d1b4c4871d9d49746d8c4d418#body_text
is schema:about of	named entity 'sheds' named entity 'levels' named entity 'The' named entity 'S. aureus' named entity 'S. aureus' named entity 'IFN-γ' named entity 'cell-mediated' named entity 'peptide' named entity 'Infection' covid:arg/8147b5b09a09887d1b4c4871d9d49746d8c4d418 named entity 'vaccines' named entity 'IL-17A' named entity 'S. aureus' named entity 'imperative' named entity 'boosting' named entity 'bacterium' named entity 'antibiotic resistance' named entity 'infections' named entity 'study' named entity 'study' named entity 'major' named entity 'Multiple' named entity 'infection' named entity 'S. aureus' named entity 'IFN-γ' named entity 'S. aureus' named entity 'spleen' named entity 'life-threatening' named entity 'mice' named entity 'peptide' named entity 'thymus' named entity 'S. aureus' named entity 'Immunization' named entity 'survival time' named entity 'immunization' named entity 'epitope' named entity 'PGN' named entity 'peptide' named entity 'vaccine' named entity 'S. aureus' named entity 'Peptide' named entity 'Peptidoglycan' named entity 'Systemic Infection' named entity 'immunized' named entity 'mimics' named entity 'CFU' named entity 'Immunization' named entity 'vaccine' named entity 'antibody' named entity 'Th17' named entity 'previously identified' named entity 'titer' named entity 'immune cells' named entity 'mice' named entity 'CD3' named entity 'IL-2' named entity '16.0' named entity 'vaccines' named entity 'clone' named entity 'kidney' named entity 'vaccine' named entity 'Th17 cells' named entity 'S. aureus' named entity 'intraperitoneal injection' named entity 'mice' named entity 'abdominal cavity' named entity 'mice' named entity 'IL-17' named entity 'mice' named entity 'mice' named entity 'IFN-γ' named entity 'mice' named entity 'cell-mediated response' named entity 'CTL'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software