About: Dynamics of neutralizing antibody titers in the months after SARS-CoV-2 infection

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About: Dynamics of neutralizing antibody titers in the months after SARS-CoV-2 infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Dynamics of neutralizing antibody titers in the months after SARS-CoV-2 infection
Creator	Bloom, Jesse Chu, Helen Logue, Jennifer Wolf, Caitlin King, Neil Casto, Amanda Crawford, Katharine Dingens, Adam Eguia, Rachel Fiala, Brooke Pettie, Deleah Shuey, Kiel Wilcox, Naomi Wrenn, Samuel
Source	MedRxiv
abstract	Most individuals infected with SARS-CoV-2 develop neutralizing antibodies that target the viral spike protein. Here we quantify how levels of these antibodies change in the months following SARS-CoV-2 infection by examining longitudinal samples collected between {approx}30 and 152 days post-symptom onset from a prospective cohort of 34 recovered individuals with asymptomatic, mild, or moderate-severe disease. Neutralizing antibody titers declined an average of about four-fold from one to four months post-symptom onset. Importantly, our data are consistent with the expected early immune response to viral infection, where an initial peak in antibody levels is followed by a decline to a lower plateau. Additional studies of long-lived B-cells and antibody titers over longer time frames are necessary to determine the durability of immunity to SARS-CoV-2.
has issue date	2020-08-07(xsd:dateTime)
bibo:doi	10.1101/2020.08.06.20169367
has license	medrxiv
sha1sum (hex)	80bad96abf3f205197f81de11b27050a829918d3
schema:url	https://doi.org/10.1101/2020.08.06.20169367
resource representing a document's title	Dynamics of neutralizing antibody titers in the months after SARS-CoV-2 infection
resource representing a document's body	covid:80bad96abf3f205197f81de11b27050a829918d3#body_text
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