About: Entry of hepatitis B and hepatitis D virus into hepatocytes: Basic insights and clinical implications

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About: Entry of hepatitis B and hepatitis D virus into hepatocytes: Basic insights and clinical implications Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Entry of hepatitis B and hepatitis D virus into hepatocytes: Basic insights and clinical implications
Creator	Li, W De, S Uni-Heidelberg, Urban, ) Urban@med, Stephan
Source	Elsevier; Medline; PMC
abstract	Summary For almost three decades following the discovery of the human Hepatitis B Virus (HBV) the early events of virus infection (attachment to hepatocytes, specific binding to a receptor on hepatocytes) remained enigmatic. The gradual improvement of tissue culture systems for HBV has enabled the identification of viral determinants for viral infectivity and facilitated the discovery of the human sodium taurocholate co-transporting polypeptide (hNTCP) as a liver specific receptor of HBV and its satellite, the human Hepatitis Delta Virus (HDV). These findings are currently leading basic and clinical research activities in new directions. (1) Stable hNTCP-expressing cell lines have become a valuable platform to study the full HBV replication cycle from its native template, the cccDNA. (2) The suitability of NTCP complemented cell culture systems for high throughput screening approaches will facilitate identification of novel host factors involved in HBV replication (including those that determine the peculiar host specificity of HBV infection) and will enable identification and development of novel drug candidates for improved therapeutics. (3) Since NTCP is a major host-specific restriction factor for HBV and HDV, hNTCP-expressing animals provide the basis for future susceptible in vivo models. (4) The concept obtained with the entry inhibitor Myrcludex B demonstrates that NTCP is a suitable target for clinical interference with viral entry. This will foster further clinical approaches aiming at curative combination therapies.
has issue date	2016-04-30(xsd:dateTime)
bibo:doi	10.1016/j.jhep.2016.02.011
bibo:pmid	27084034
has license	els-covid
sha1sum (hex)	8097952f917ec4d94c196d2c672dece4a64de1d1
schema:url	https://doi.org/10.1016/j.jhep.2016.02.011
resource representing a document's title	Entry of hepatitis B and hepatitis D virus into hepatocytes: Basic insights and clinical implications
has PubMed Central identifier	PMC7114860
has PubMed identifier	27084034
schema:publication	Journal of Hepatology
resource representing a document's body	covid:8097952f917ec4d94c196d2c672dece4a64de1d1#body_text
is schema:about of	named entity 'RAT' named entity 'ENTRY' named entity 'S32' named entity 'NTCP' named entity 'S36' named entity 'SPECIFICITY' named entity 'S40' named entity 'INFECT' named entity 'VIRAL INFECTION' named entity 'PRIMATES' named entity 'REVIEW' named entity 'HUMAN' named entity 'HBV' named entity 'LEVEL' named entity 'INFECTS' named entity 'MOUSE' named entity 'NORTHERN' named entity 'CHIMPANZEES' named entity 'NTCP' named entity 'virus' named entity 'protein' named entity 'entry inhibitors' named entity 'pseudotyped' named entity 'seroconversion' named entity 'envelope proteins' named entity 'genotype' named entity 'virus receptor' named entity 'receptor binding' named entity 'hepatocytes' named entity 'subcutaneously' named entity 'enterohepatic circulation' named entity 'HBV' named entity 'HDV' named entity 'high throughput screening' named entity 'amino acids' named entity 'peptides' named entity 'single point mutation' named entity 'cell lines' named entity 'HIV' named entity 'lipopeptides' named entity 'cellular receptors' named entity 'NTCP' named entity 'endogenous' named entity 'therapeutic effects' named entity 'intracellular' named entity 'HBV' named entity 'virus receptor' named entity 'suramin' named entity 'NTCP' named entity 'infectivity' named entity 'viruses' named entity 'CHB' named entity 'NTCP' named entity 'mice' named entity 'WMHBV' named entity 'hepatocytes' named entity 'hepatocytes' named entity 'Biochemical studies' named entity 'HBV' named entity 'virus' named entity 'cellular receptor' named entity 'hepatitis C virus (HCV) infection' named entity 'cccDNA' named entity 'molecule' named entity 'HCC' named entity 'antiviral activity' named entity 'C57BL/6' named entity 'circular DNA' named entity 'infection' named entity 'control arm' named entity 'peptidic' named entity 'saccharides' named entity 'mammals' named entity 'immune responses' named entity 'HBV' named entity 'envelope protein' named entity 'antigenic'

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