About: Newcastle Disease Virus as a Vaccine Vector for 20 Years: A Focus on Maternally Derived Antibody Interference

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Newcastle Disease Virus as a Vaccine Vector for 20 Years: A Focus on Maternally Derived Antibody Interference
Creator	Liu, Xiufan Hu, Zenglei Cao, Yongzhong Ni, Jie
Source	Medline; PMC
abstract	It has been 20 years since Newcastle disease virus (NDV) was first used as a vector. The past two decades have witnessed remarkable progress in vaccine generation based on the NDV vector and optimization of the vector. Protective antigens of a variety of pathogens have been expressed in the NDV vector to generate novel vaccines for animals and humans, highlighting a great potential of NDV as a vaccine vector. More importantly, the research work also unveils a major problem restraining the NDV vector vaccines in poultry, i.e., the interference from maternally derived antibody (MDA). Although many efforts have been taken to overcome MDA interference, a lack of understanding of the mechanism of vaccination inhibition by MDA in poultry still hinders vaccine improvement. In this review, we outline the history of NDV as a vaccine vector by highlighting some milestones. The recent advances in the development of NDV-vectored vaccines or therapeutics for animals and humans are discussed. Particularly, we focus on the mechanisms and hypotheses of vaccination inhibition by MDA and the efforts to circumvent MDA interference with the NDV vector vaccines. Perspectives to fill the gap of understanding concerning the mechanism of MDA interference in poultry and to improve the NDV vector vaccines are also proposed.
has issue date	2020-05-14(xsd:dateTime)
bibo:doi	10.3390/vaccines8020222
bibo:pmid	32422944
has license	cc-by
sha1sum (hex)	8051a3ee1be3b89794a0de30110b245a2ba81413
schema:url	https://doi.org/10.3390/vaccines8020222
resource representing a document's title	Newcastle Disease Virus as a Vaccine Vector for 20 Years: A Focus on Maternally Derived Antibody Interference
has PubMed Central identifier	PMC7349365
has PubMed identifier	32422944
schema:publication	Vaccines (Basel)
resource representing a document's body	covid:8051a3ee1be3b89794a0de30110b245a2ba81413#body_text
is schema:about of	named entity 'highlighting' named entity 'MDA' named entity 'poultry' named entity 'improve' named entity 'animals' named entity 'vector' named entity 'THERAPEUTICS' named entity 'GENERATE' named entity 'VACCINE GENERATION' named entity 'FOCUS' named entity 'POULTRY' named entity 'VECTOR' named entity 'DEVELOPMENT' named entity 'HUMANS' named entity 'VARIETY' named entity 'UNDERSTANDING' named entity 'REVIEW' named entity 'MECHANISMS' named entity 'A MAJOR' named entity 'Perspectives' named entity 'vector' named entity 'variety' named entity 'vector' named entity 'therapeutics' named entity 'vaccine' named entity 'MDA' named entity 'vaccines' named entity 'vaccine' named entity 'poultry' named entity 'poultry' named entity 'vector' named entity 'vector' named entity 'vector' named entity 'vaccination' named entity 'pathogens' named entity 'vector' named entity 'NDV' named entity 'vaccine' named entity 'vaccine' named entity 'vector' named entity 'poultry' named entity 'vector' named entity 'Newcastle Disease Virus' named entity 'NDV' named entity 'protein' named entity 'avian influenza' named entity 'poultry' named entity 'ADCP' named entity 'cellular immunity' named entity 'PD1' named entity 'vector virus' named entity 'epitope' named entity 'neonatal' named entity 'H5N2' named entity 'NDV' named entity 'vaccination' named entity 'neutralizing antibodies' named entity 'NDV' named entity 'NDV' named entity 'GFP' named entity 'bottleneck' named entity 'neutralizing antibodies' named entity 'transcription' named entity 'multiple genes' named entity 'administrated' named entity 'cDNA clone' named entity 'NDV' named entity 'NDV' named entity 'neonates' named entity 'recombinant virus' named entity 'virus genome' named entity 'chimeric' named entity 'human medicine' named entity 'immunology' named entity 'deficient mice' named entity 'gene' named entity 'antibody response' named entity 'vaccination'

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