About: Asymptomatic Shedding of Respiratory Virus among an Ambulatory Population across Seasons

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Asymptomatic Shedding of Respiratory Virus among an Ambulatory Population across Seasons
Creator	Birger, Ruthie Comito, Devon Desalle, Rob Filip, Ioan Galanti, Marta Lane, Benjamin Ligon, Chanel Morita, Haruka Planet, Paul Rosenbloom, Daniel Shaman, Jeffrey Shittu, Atinuke Ud-Dean, Minhaz
Source	Medline; PMC
abstract	Most observation of human respiratory virus carriage is derived from medical surveillance; however, the infections documented by this surveillance represent only a symptomatic fraction of the total infected population. As the role of asymptomatic infection in respiratory virus transmission is still largely unknown and rates of asymptomatic shedding are not well constrained, it is important to obtain more-precise estimates through alternative sampling methods. We actively recruited participants from among visitors to a New York City tourist attraction. Nasopharyngeal swabs, demographics, and survey information on symptoms, medical history, and recent travel were obtained from 2,685 adults over two seasonal arms. We used multiplex PCR to test swab specimens for a selection of common respiratory viruses. A total of 6.2% of samples (168 individuals) tested positive for at least one virus, with 5.6% testing positive in the summer arm and 7.0% testing positive in the winter arm. Of these, 85 (50.6%) were positive for human rhinovirus (HRV), 65 (38.7%) for coronavirus (CoV), and 18 (10.2%) for other viruses (including adenovirus, human metapneumovirus, influenza virus, and parainfluenza virus). Depending on the definition of symptomatic infection, 65% to 97% of infections were classified as asymptomatic. The best-fit model for prediction of positivity across all viruses included a symptom severity score, Hispanic ethnicity data, and age category, though there were slight differences across the seasonal arms. Though having symptoms is predictive of virus positivity, there are high levels of asymptomatic respiratory virus shedding among the members of an ambulatory population in New York City. IMPORTANCE Respiratory viruses are common in human populations, causing significant levels of morbidity. Understanding the distribution of these viruses is critical for designing control methods. However, most data available are from medical records and thus predominantly represent symptomatic infections. Estimates for asymptomatic prevalence are sparse and span a broad range. In this study, we aimed to measure more precisely the proportion of infections that are asymptomatic in a general, ambulatory adult population. We recruited participants from a New York City tourist attraction and administered nasal swabs, testing them for adenovirus, coronavirus, human metapneumovirus, rhinovirus, influenza virus, respiratory syncytial virus, and parainfluenza virus. At recruitment, participants completed surveys on demographics and symptomology. Analysis of these data indicated that over 6% of participants tested positive for shedding of respiratory virus. While participants who tested positive were more likely to report symptoms than those who did not, over half of participants who tested positive were asymptomatic.
has issue date	2018-07-11(xsd:dateTime)
bibo:doi	10.1128/msphere.00249-18
bibo:pmid	29997120
has license	cc-by
sha1sum (hex)	7ffbca7e7e60e13461801769ad70f770879d0f81
schema:url	https://doi.org/10.1128/msphere.00249-18
resource representing a document's title	Asymptomatic Shedding of Respiratory Virus among an Ambulatory Population across Seasons
has PubMed Central identifier	PMC6041500
has PubMed identifier	29997120
schema:publication	mSphere
resource representing a document's body	covid:7ffbca7e7e60e13461801769ad70f770879d0f81#body_text
is schema:about of	named entity 'levels' named entity 'While' named entity 'ambulatory' named entity 'individuals' named entity 'shedding' named entity 'tourist attraction' named entity 'adults' named entity 'positive' named entity 'respiratory' named entity 'Population' named entity 'POPULATION' named entity 'SEASONS' named entity 'ANALYSIS' named entity 'IMPORTANT' named entity 'MEDICAL SURVEILLANCE' named entity 'CONSTRAINED' named entity 'RHINOVIRUS' named entity 'SWABS' named entity 'UNDERSTANDING' named entity 'MEDICAL HISTORY' named entity 'SIGNIFICANT' named entity 'ETHNICITY DATA' named entity 'NEW YORK CITY' named entity 'BROAD' named entity 'IS DERIVED FROM' named entity 'TOURIST' named entity 'PROPORTION' named entity 'HALF' named entity 'TO MEASURE' named entity 'INFECTION' named entity 'TOTAL' named entity 'TO TEST' named entity 'SLIGHT' named entity 'POSITIVE FOR' named entity 'SPECIMENS' named entity 'HUMAN RHINOVIRUS' named entity 'ROLE' named entity 'AVAILABLE' named entity 'ADMINISTERED' named entity 'SURVEILLANCE' named entity 'PREDICTIVE' named entity '6.2' named entity 'OBSERVATION' named entity 'SYMPTOMOLOGY' named entity 'ACROSS' named entity 'INCLUDED' named entity 'SYMPTOM SEVERITY' named entity 'TRAVEL' named entity 'LARGELY' named entity 'METHODS' named entity 'ALTERNATIVE' named entity 'SYMPTOMATIC' named entity 'SEVERITY SCORE' named entity 'SAMPLES' named entity 'ARM' named entity 'PREVALENCE' named entity 'SUMMER' named entity 'POSITIVE' named entity 'INFECTED POPULATION' named entity 'OBTAIN' named entity 'VIRUS SHEDDING' named entity 'HISPANIC' named entity 'ARMS' named entity 'WINTER' named entity 'RECENT' named entity 'HUMAN' named entity 'ASYMPTOMATIC INFECTION' named entity 'OBTAINED' named entity 'ADULTS'

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