About: Is the use of RAS inhibitors safe in the current era of COVID-19 pandemic?

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About: Is the use of RAS inhibitors safe in the current era of COVID-19 pandemic? Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Is the use of RAS inhibitors safe in the current era of COVID-19 pandemic?
Creator	Shin, Jinho Lee, Hae Sung, Ki Kim, Hyeon Cho, Eun Chung, Wook-Jin Ihm, Sang-Hyun Kim, Dae-Hee Kim, Juhan Park, Sungha Ryu, Sung Sohn, Il-Suk Kim, Kwang-Il
source	Medline; PMC
abstract	Antihypertensive drugs are one of the most widely used pharmacologic agent in the world and it is predominantly used in the elderly subjects. Pneumonia is the most common cause of death in the extremely old subject. During infection and its complication such as sepsis, hypotension could be exacerbated by antihypertensive drugs because homeostasis mechanisms such as sodium balance, renin angiotensin aldosterone system and/or sympathetic nervous system can be mitigated by antihypertensive drug therapy. Severe Acute Respiratory Syndrome-Coronavirus-1 and 2 viral surface protein is known to attach angiotensin converting enzyme 2 (ACE2) on the cell membrane to facilitate viral entry into the cytoplasm. Despite the theoretical concerns of increased ACE2 expression by Renin-Angiotensin-Aldosterone system (RAS) blockade, there is no evidence that RAS inhibitors are harmful during COVID-19 infection and have in fact been shown to be beneficial in animal studies. Therefore, it is recommended to maintain RAS blockade during the current corona virus pandemic.
has issue date	2020-05-07(xsd:dateTime)
bibo:doi	10.1186/s40885-020-00144-0
bibo:pmid	32391169
has license	cc-by
sha1sum (hex)	7f7e827d3b7505f380f6f6c77eceea6207b98f82
schema:url	https://doi.org/10.1186/s40885-020-00144-0
resource representing a document's title	Is the use of RAS inhibitors safe in the current era of COVID-19 pandemic?
has PubMed Central identifier	PMC7202902
has PubMed identifier	32391169
schema:publication	Clin Hypertens
resource representing a document's body	covid:7f7e827d3b7505f380f6f6c77eceea6207b98f82#body_text
is schema:about of	named entity 'blockade' named entity 'converting' named entity 'Acute' named entity 'aldosterone' named entity 'RAS' named entity 'angiotensin' named entity 'mitigated' named entity 'hypotension' named entity 'infection' named entity 'pandemic' named entity 'KNOWN' named entity 'EVIDENCE' named entity 'INFECTION' named entity 'ITS' named entity 'ELDERLY SUBJECTS' named entity 'VIRUS' named entity 'expression' named entity 'renin' named entity 'homeostasis' named entity 'maintain' named entity 'viral entry' named entity 'viral' named entity 'animal studies' named entity 'viral entry' named entity 'COVID' named entity 'infection' named entity 'RAS' named entity 'Renin-Angiotensin-Aldosterone' named entity 'ACE2' named entity 'angiotensin converting enzyme 2' named entity 'aldosterone' named entity 'angiotensin' named entity 'testis' named entity 'antihypertensive drugs' named entity 'ADAM17' named entity 'viral entry' named entity '3, 4' named entity 'acute kidney injury' named entity 'ACE2' named entity 'Angiotensin' named entity 'lung' named entity 'infection' named entity 'septic shock' named entity 'mortality rates' named entity 'SARS-CoV-1' named entity 'influenza' named entity 'lung' named entity 'ACE2' named entity 'hypertension' named entity 'SARS-CoV-1' named entity 'biochemical pathway' named entity 'hypertension' named entity 'antihypertensive agents' named entity 'hypertension' named entity 'European Society of Cardiology' named entity 'hypotension' named entity 'ACE2' named entity 'hypertension' named entity 'Antihypertensive drug' named entity 'ACE2' named entity 'mice' named entity 'ACE2' named entity 'complications of hypertension' named entity 'influenza' named entity 'flu' named entity 'lower respiratory tract infection' named entity 'infection' named entity 'septic shock' named entity 'prognosis'

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