About: Viral factors in influenza pandemic risk assessment

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Viral factors in influenza pandemic risk assessment
Creator	Herfst, Sander Lipsitch, Marc Riley, Steven Maurer-Stroh, Sebastian Roche, Benjamin Barclay, Wendy Bedford, Trevor Cobey, Sarah Handel, Andreas Raman, Rahul Belser, Jessica Friedrich, Thomas Kasson, Peter Murcia, Pablo Russell, Charles Russell, Colin Wilke, Claus Aa Beauchemin, Catherine
source	PMC
abstract	The threat of an influenza A virus pandemic stems from continual virus spillovers from reservoir species, a tiny fraction of which spark sustained transmission in humans. To date, no pandemic emergence of a new influenza strain has been preceded by detection of a closely related precursor in an animal or human. Nonetheless, influenza surveillance efforts are expanding, prompting a need for tools to assess the pandemic risk posed by a detected virus. The goal would be to use genetic sequence and/or biological assays of viral traits to identify those non-human influenza viruses with the greatest risk of evolving into pandemic threats, and/or to understand drivers of such evolution, to prioritize pandemic prevention or response measures. We describe such efforts, identify progress and ongoing challenges, and discuss three specific traits of influenza viruses (hemagglutinin receptor binding specificity, hemagglutinin pH of activation, and polymerase complex efficiency) that contribute to pandemic risk. DOI: http://dx.doi.org/10.7554/eLife.18491.001
has issue date	2016-11-11(xsd:dateTime)
bibo:doi	10.7554/elife.18491
bibo:pmid	27834632
has license	cc0
sha1sum (hex)	7f2079d6e5244be0e38c55fe08a1c1672ab645fb
schema:url	https://doi.org/10.7554/elife.18491
resource representing a document's title	Viral factors in influenza pandemic risk assessment
has PubMed Central identifier	PMC5156527
has PubMed identifier	27834632
resource representing a document's body	covid:7f2079d6e5244be0e38c55fe08a1c1672ab645fb#body_text
is schema:about of	named entity 'specificity' named entity 'describe' named entity 'The goal' named entity 'hemagglutinin' named entity 'influenza pandemic' named entity 'INFLUENZA PANDEMIC' named entity 'RISK ASSESSMENT' named entity 'PROMPTING' named entity 'CHALLENGES' named entity 'NEW' named entity 'HEMAGGLUTININ' named entity 'MEASURES' named entity 'EMERGENCE' named entity 'INFLUENZA SURVEILLANCE' named entity 'EFFICIENCY' named entity 'RESPONSE' named entity 'INFLUENZA VIRUSES' named entity 'HUMAN INFLUENZA' named entity 'PANDEMIC' named entity 'ASSESS' named entity 'NON-' named entity 'SPARK' named entity 'ONGOING' named entity 'POLYMERASE' named entity 'DATE' named entity 'HUMAN' named entity 'EVOLUTION' named entity 'DISCUSS' named entity 'THREATS' named entity 'PREVENTION' named entity 'TOOLS' named entity 'FRACTION OF' named entity 'IDENTIFY' named entity 'STRAIN' named entity 'ANIMAL' named entity 'GREATEST' named entity 'SUSTAINED' named entity 'CONTRIBUTE ' named entity 'RECEPTOR BINDING' named entity 'NEED FOR' named entity 'RESERVOIR' named entity 'DESCRIBE' named entity 'TRANSMISSION' named entity 'VIRAL' named entity 'VIRUS' named entity 'GOAL' named entity 'PROGRESS' named entity 'SPECIFIC' named entity 'TINY' named entity 'STEMS' named entity 'UNDERSTAND' named entity 'PRECEDED' named entity 'EVOLVING' named entity 'TO IDENTIFY' named entity 'DRIVERS' named entity 'RISK' named entity 'BINDING SPECIFICITY' named entity 'DETECTION' named entity 'DETECTED' named entity 'HUMANS' named entity 'RELATED' named entity 'INFLUENZA' named entity 'COMPLEX' named entity 'SPECIES' named entity 'TRAITS'

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