About: Respiratory disease and lower pulmonary function as risk factors for subsequent dementia: a systematic review with meta-analysis

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About: Respiratory disease and lower pulmonary function as risk factors for subsequent dementia: a systematic review with meta-analysis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Respiratory disease and lower pulmonary function as risk factors for subsequent dementia: a systematic review with meta-analysis
Creator	Russ, Tom David Batty Dsc, G Fmedsci, Mika Scotland, Alzheimer
Source	BioRxiv
abstract	Background In addition to affecting the oxygen supply to the brain, pulmonary function is a marker of multiple insults throughout life (including smoking, illness, and socioeconomic deprivation). By meta-analysing existing studies, we tested the hypothesis that lower pulmonary function and respiratory illness are linked to an elevated risk of dementia. Aims To review the best available evidence, taken from longitudinal studies, for pulmonary function and respiratory disease as risk factors of dementia. Method We conducted a systematic review of longitudinal studies using PubMed until April 1st, 2019 and, where possible, pooled results in random-effects meta-analyses. Results We identified eleven studies relating pulmonary function to later dementia risk, and eleven studies of respiratory illness and dementia (including one which studied both). The lowest quartile of lung function measure Forced Expiratory Volume in one second (FEV1) compared with the highest was associated with a 1.5-fold (1.51, 95%CI 0.94-2.42) increased dementia risk (Ntotal=127,710, 3 studies). Respiratory illness was also associated with increased dementia risk to a similar degree (1.54, 1.30-1.81, Ntotal=288,641, 11 studies). Conclusions Individuals with poor pulmonary function are at increased risk of dementia. The extent to which the association between poor pulmonary function and dementia is causal remains unclear.
has issue date	2019-04-19(xsd:dateTime)
bibo:doi	10.1101/602193
has license	biorxiv
sha1sum (hex)	7eeb16593ff1a418c656eac33e10b9ea23808730
schema:url	https://doi.org/10.1101/602193
resource representing a document's title	Respiratory disease and lower pulmonary function as risk factors for subsequent dementia: a systematic review with meta-analysis
schema:publication	bioRxiv
resource representing a document's body	covid:7eeb16593ff1a418c656eac33e10b9ea23808730#body_text
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