About: Non-invasive pressure support ventilation in severe community-acquired pneumonia

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Non-invasive pressure support ventilation in severe community-acquired pneumonia
Creator	Abajo, Blanca Abajo´p, ´b Chevrolet, Jean-Claude Jolliet, P Jolliet, Philippe Pasquina, B Pasquina, Patrick Pasquinaj, Therapy, Respiratory
Source	PMC
abstract	Objective: To explore three aspects of non-invasive pressure support ventilation (NIPSV) applied by face mask to patients with acute respiratory failure (ARF) due to severe community-acquired pneumonia (CAP): (1) the initial acute effects on respiratory rate, gas exchange and hemodynamics, (2) the clinical course and outcome during ICU and hospital stay, (3) the nursing workload as measured by the daily PRN 87 (Project Research in Nursing) score. Setting: Medical ICU, University Hospital. Design: Prospective, observational study. Patients: Patients without any prior history of chronic lung disease, consecutively admitted to the ICU to receive NIPSV for ARF due to severe CAP. Measurements and results (means ± SD): Twenty-four patients aged 49±17 years, admission APACHE II 13±5, were included. Admission PaO(2)/FIO(2), alveolar-arterial oxygen difference (DA-aO(2)) and PaCO(2) were 104±48, 447±120 and 40±10 mmHg, respectively. All patients were normotensive. During the initial NIPSV trial respiratory rate decreased from 34±8 to 28±10 breaths/min (p<0.001) and arterial oxygenation improved (PaO(2)/FIO(2) 104±48 vs 153±49, DA-aO(2) 447±120 vs 370±180 mmHg, p<0.001) while PaCO(2) remained unchanged. There were no hemodynamic effects. Subsequently, a total of 133 NIPSV trials were performed (median duration 55 min, range 30–540 min) over 1–7 days. No complication occurred during NIPSV. Sixteen patients were intubated (66%) 1.3±1 days after inclusion. Upon inclusion, the patients who were subsequently intubated were older (55±15 vs 37±12 years) and more severely hypoxemic (63±11 vs 80±15 mmHg, p<0.05) than those not requiring intubation. Eight patients died (33%), all in the intubated group. Median lengths of stay in the ICU and hospital were longer in intubated patients (ICU 16 days, range 3–64 vs 6 days, range 3–7, p<0.05; hospital 23 days, range 9–77 vs 9.5 days, range 4–42, p<0.05). Mean daily total PRN points were stable throughout the NIPSV period and were not different between the groups. Only 14% of PRN points resulted from respiratory therapy interventions. PRN score was higher during the first 24 h following intubation than during the first 24 h of NIPSV (278±55 vs 228±24 points, p<0.05). Conclusion: Despite initial improvement in arterial oxygenation with NIPSV in patients with ARF due to severe CAP, the intubation rate is high. However, the more favorable outcome and shorter ICU and hospital stays when intubation is avoided, as well as the short delay required to assess the success or failure of NIPSV warrants a trial of NIPSV in this setting. The nursing workload remains stable during NIPSV and does not result predominantly from respiratory therapy interventions.
has issue date	2001-04-27(xsd:dateTime)
bibo:doi	10.1007/s001340100869
bibo:pmid	11430536
has license	no-cc
sha1sum (hex)	7ec732c7eb588241b9062e46d922bfef7aca6354
schema:url	https://doi.org/10.1007/s001340100869
resource representing a document's title	Non-invasive pressure support ventilation in severe community-acquired pneumonia
has PubMed Central identifier	PMC7095297
has PubMed identifier	11430536
schema:publication	Intensive Care Med
resource representing a document's body	covid:7ec732c7eb588241b9062e46d922bfef7aca6354#body_text
is schema:about of	named entity 'range' named entity 'acute' named entity 'workload' named entity 'PRN' named entity 'respiratory rate' named entity 'Measurements' named entity 'hemodynamics' named entity 'All' named entity 'community-acquired pneumonia' named entity 'APPLIED' named entity 'ADMISSION' named entity 'RESEARCH' named entity 'CONCLUSION' named entity 'HEMODYNAMIC' named entity 'PRESSURE SUPPORT VENTILATION' named entity 'DIED' named entity '2855' named entity 'ACUTE RESPIRATORY FAILURE' named entity 'OBJECTIVE' named entity 'MEAN' named entity 'HIGHER' named entity 'OXYGEN' named entity 'PRIOR' named entity 'WORKLOAD' named entity 'GROUP' named entity '120' named entity 'LENGTHS' named entity 'ICU' named entity 'ARF' named entity 'stay' named entity 'respiratory therapy' named entity 'gas exchange' named entity 'range' named entity 'Despite' named entity 'hospital' named entity 'daily' named entity 'history' named entity 'admission' named entity 'University Hospital' named entity 'intubation' named entity 'days' named entity 'hospital' named entity 'patients' named entity 'oxygenation' named entity 'remained' named entity 'Med' named entity 'intubated' named entity '7 days' named entity 'improvement' named entity 'Non-invasive' named entity 'CAP' named entity 'hemodynamic effects' named entity 'ICU' named entity 'Intensive Care' named entity 'chronic lung disease' named entity 'mmHg' named entity 'ICU' named entity 'respiratory therapy' named entity 'intubated' named entity 'non-invasive' named entity 'intubated' named entity 'intubation' named entity 'intubated' named entity 'respiratory rate' named entity 'mmHg' named entity 'CAP' named entity 'ICU' named entity 'community-acquired pneumonia' named entity 'arterial' named entity 'Median' named entity 'PRN' named entity 'mechanical ventilation' named entity '7.30'

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