About: Chapter 19 Advantages and Limitations of Commonly Used Nonhuman Primate Species in Research and Development of Biopharmaceuticals

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Chapter 19 Advantages and Limitations of Commonly Used Nonhuman Primate Species in Research and Development of Biopharmaceuticals Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Chapter 19 Advantages and Limitations of Commonly Used Nonhuman Primate Species in Research and Development of Biopharmaceuticals
Creator	Brennan, Frank Peters, Christopher Cauvin, Annick
Source	Elsevier; PMC
abstract	Abstract Nonhuman primates (NHPs) have been used extensively during the past four decades for research and nonclinical development because they are close to humans in terms of genetics, anatomy, physiology, and immunology. They have been widely used in the development of infection models, leading to the generation of vaccines and drugs, as well as in the nonclinical pharmacologic and toxicologic assessment of biopharmaceuticals, especially in the fields of immunotherapy and oncology, despite the constant pressure to move to lower species. In many cases, NHPs are the only species that allows a correct risk assessment for humans. Nevertheless, limitations inherent to each species have to be considered before an investigation. This chapter shines some light on the respective interests and limitations of using cynomolgus monkeys, rhesus monkeys, and marmosets in medical research and nonclinical development, with a specific focus on reproduction and immunology.
has issue date	2015-12-31(xsd:dateTime)
bibo:doi	10.1016/b978-0-12-417144-2.00019-6
has license	els-covid
sha1sum (hex)	7eba6e8d93dc93df02dc0573cfad6a3a01031781
schema:url	https://doi.org/10.1016/b978-0-12-417144-2.00019-6
resource representing a document's title	Chapter 19 Advantages and Limitations of Commonly Used Nonhuman Primate Species in Research and Development of Biopharmaceuticals
has PubMed Central identifier	PMC7149394
schema:publication	The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment
resource representing a document's body	covid:7eba6e8d93dc93df02dc0573cfad6a3a01031781#body_text
is schema:about of	named entity 'Research' named entity 'SPECIES' named entity 'USED' named entity 'BIOPHARMACEUTICALS' named entity 'LIMITATIONS' named entity 'RESEARCH AND DEVELOPMENT' named entity 'NONHUMAN PRIMATE' named entity 'pregnancy' named entity 'safety assessment' named entity 'biopharmaceuticals' named entity 'bronchial asthma' named entity 'cynomolgus monkey' named entity 'NHP' named entity 'Gestation' named entity 'organogenesis' named entity 'human remains' named entity 'measles' named entity 'lymphoma' named entity 'omalizumab' named entity 'blood group' named entity 'cytokines' named entity 'canakinumab' named entity 'rodent' named entity 'study designs' named entity 'Hematology' named entity 'cell line' named entity 'prostate' named entity 'cynomolgus monkey' named entity 'complement-dependent cytotoxicity' named entity 'recombinant proteins' named entity 'toxicology' named entity 'Toll-like receptor' named entity 'cervix' named entity 'IgG' named entity 'breeding colonies' named entity 'MHC' named entity 'saimiri' named entity 'gestation' named entity 'FcγRIIIB' named entity 'marmosets' named entity 'Siglec' named entity 'pathogen' named entity 'genome' named entity 'pregnancy' named entity 'mAbs' named entity 'FcγR' named entity 'genomes' named entity 'reproductive toxicity' named entity 'genetic differences' named entity 'toxicology' named entity 'platelet' named entity 'China' named entity 'human physiology' named entity 'lymphocytes' named entity 'public domain' named entity 'postpartum' named entity 'lysis' named entity 'rhesus macaque' named entity 'cerebellar' named entity 'phagocytosis' named entity 'Perinatal' named entity 'maternal mortality' named entity 'EBV' named entity 'cynomolgus macaques' named entity 'postpartum' named entity 'inflammation' named entity 'cynomolgus' named entity 'fetal development' named entity 'EFD' named entity 'recombinant proteins' named entity 'rhesus macaque' named entity 'antibodies' named entity 'biologics' named entity 'fetal death' named entity 'IL-4R' named entity 'mAbs' named entity 'immunotherapies' named entity 'rhesus monkeys' named entity 'hemorrhage' named entity 'sequence identity' named entity 'loci'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software