About: RNA sensors of the innate immune system and their detection of pathogens

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	RNA sensors of the innate immune system and their detection of pathogens
Creator	Xia, Pengpeng Zhu, Jianzhong Wang, Tony Chen, Nanhua Li, Shuangjie Zhang, Tangjie
Source	Medline; PMC
abstract	The innate immune system plays a critical role in pathogen recognition and initiation of protective immune response through the recognition of pathogen associated molecular patterns (PAMPs) by its pattern recognition receptors (PRRs). Nucleic acids including RNA and DNA have been recognized as very important PAMPs of pathogens especially for viruses. RNA are the major PAMPs of RNA viruses, to which most severe disease causing viruses belong thus posing a tougher challenge to human and animal health. Therefore, the understanding of the immune biology of RNA PRRs is critical for control of pathogen infections especially for RNA virus infections. RNA PRRs are comprised of TLR3, TLR7, TLR8, RIG‐I, MDA5, NLRP3, NOD2, and some other minorities. This review introduces these RNA PRRs by describing the cellular localizations, ligand recognitions, activation mechanisms, cell signaling pathways, and recognition of pathogens; the cross‐talks between various RNA PRRs are also reviewed. The deep insights of these RNA PRRs can be utilized to improve anti‐viral immune response. © 2017 IUBMB Life, 69(5):297–304, 2017
has issue date	2017-04-04(xsd:dateTime)
bibo:doi	10.1002/iub.1625
bibo:pmid	28374903
has license	no-cc
sha1sum (hex)	7e8b3e811509c82071102d87d674507dcb523e91
schema:url	https://doi.org/10.1002/iub.1625
resource representing a document's title	RNA sensors of the innate immune system and their detection of pathogens
has PubMed Central identifier	PMC7165898
has PubMed identifier	28374903
schema:publication	IUBMB Life
resource representing a document's body	covid:7e8b3e811509c82071102d87d674507dcb523e91#body_text
is schema:about of	named entity 'Pathogens' named entity 'RNA' named entity 'Innate Immune' named entity 'mRNA' named entity 'RNA' named entity 'monocytes' named entity 'monomer' named entity 'virus infections' named entity 'PRRs' named entity 'RIG-I' named entity 'TLR8' named entity 'reovirus' named entity 'nucleic acids' named entity 'rhabdovirus' named entity 'influenza virus' named entity 'RNA' named entity 'immune responses' named entity 'dimerization' named entity 'TLR7' named entity 'poly I:C' named entity 'TLR8' named entity 'cytoplasmic' named entity 'PRRs' named entity 'miRNA' named entity 'MyD88' named entity 'PYD' named entity 'TLR3' named entity 'TLRs' named entity 'DHX36' named entity 'virus' named entity 'DDX3' named entity 'MCMV' named entity 'viruses' named entity 'chemokines' named entity 'arginine' named entity 'innate immune' named entity 'pathogens' named entity 'TRAF6' named entity 'solenoid' named entity 'cytokines' named entity 'mitochondria' named entity 'VSV' named entity 'cholesterol' named entity 'RNA viruses' named entity 'interferon' named entity 'non-self' named entity 'Streptococcus pyogenes' named entity 'crystal structure' named entity 'RNA' named entity 'virus infection' named entity 'West Nile Virus' named entity 'effector domains' named entity 'RNA' named entity 'anti-viral' named entity 'C-terminal' named entity 'viruses' named entity 'gene transcription' named entity 'polyubiquitination' named entity 'cell signaling' named entity 'IFN' named entity 'pathogen' named entity 'ligands' named entity 'IFN' named entity 'poliovirus' named entity 'adenovirus' named entity 'TLR8' named entity 'NOD2' named entity 'Shigella flexneri' named entity 'ligand' named entity 'RNA virus infections' named entity 'nigericin' named entity 'JEV' named entity 'dsRNA' named entity 'proinflammatory cytokines' named entity 'intracellular signaling' named entity 'RNA'

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