About: Activation of c-Jun N-terminal kinase by Akabane virus is required for apoptosis

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Activation of c-Jun N-terminal kinase by Akabane virus is required for apoptosis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Activation of c-Jun N-terminal kinase by Akabane virus is required for apoptosis
Creator	Furuya, T Mizutani, T Mitomo, S Nagai, M Omatsu, T Tsuchiaka, S
Source	Elsevier; Medline; PMC
abstract	Abstract Akabane virus (AKAV) belongs to the Simbu serogroup of the genus Orthobunyavirus in the family Bunyaviridae. It has been shown that AKAV induces apoptosis in mammalian cells. It is necessary to understand the signaling pathways involved in AKAV-induced apoptosis to further elucidate the molecular virology of AKAV. c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) are mediators of apoptosis; therefore, we investigated the roles of JNK and p38 MAPK cascades in AKAV-infected cells. We found that JNK and p38 MAPK as well as their downstream substrates, c-Jun and heat shock protein 27 (HSP27), were phosphorylated in response to AKAV infection. A JNK inhibitor (SP600125) inhibited AKAV-mediated apoptosis whereas a p38 MAPK inhibitor (SB203580) did not. We conclude that AKAV infection activates the JNK and p38 MAPK signaling pathways, and the JNK cascade plays a crucial role in AKAV-induced apoptosis in vitro.
has issue date	2016-08-31(xsd:dateTime)
bibo:doi	10.1016/j.rvsc.2016.06.007
bibo:pmid	27473988
has license	els-covid
sha1sum (hex)	7e51d91074212ae3b7facd94bdb48c6f21bc0655
schema:url	https://doi.org/10.1016/j.rvsc.2016.06.007
resource representing a document's title	Activation of c-Jun N-terminal kinase by Akabane virus is required for apoptosis
has PubMed Central identifier	PMC7111864
has PubMed identifier	27473988
schema:publication	Research in Veterinary Science
resource representing a document's body	covid:7e51d91074212ae3b7facd94bdb48c6f21bc0655#body_text
is schema:about of	named entity 'C-JUN N-TERMINAL KINASE' named entity 'inhibitor' named entity 'JNK' named entity 'p38 MAPK' named entity 'activates' named entity 'p38 MAPK' named entity 'Akabane virus' named entity 'CELLS' named entity 'INFECTION' named entity 'JNK CASCADE' named entity 'HEAT SHOCK PROTEIN 27' covid:arg/7e51d91074212ae3b7facd94bdb48c6f21bc0655 named entity 'JNK' named entity 'INFECTED' named entity 'GENUS ORTHOBUNYAVIRUS' named entity 'INHIBITED' named entity 'MAMMALIAN' named entity 'RESPONSE TO' named entity 'REQUIRED' named entity 'MOLECULAR VIROLOGY' named entity 'SIMBU SEROGROUP' named entity 'APOPTOSIS' named entity 'ACTIVATION' named entity 'ROLES' named entity 'P38 MAPK SIGNALING' named entity 'INVOLVED' named entity 'DID' named entity 'UNDERSTAND' named entity 'CONCLUDE' named entity 'DOWNSTREAM' named entity 'THEIR' named entity 'PHOSPHORYLATED' named entity 'SIGNALING PATHWAYS' named entity 'FAMILY BUNYAVIRIDAE' named entity 'NECESSARY' named entity 'P38 MAPK' named entity 'ACTIVATES' named entity 'FOUND' named entity 'MEDIATED' named entity 'PLAYS' named entity 'C-JUN N-TERMINAL KINASE' named entity 'AKABANE VIRUS' named entity 'INDUCED' named entity 'APOPTOSIS' named entity 'P38 MITOGEN-ACTIVATED PROTEIN KINASE' named entity 'MEDIATORS' named entity 'JNK INHIBITOR' named entity 'C-JUN' named entity 'AKABANE VIRUS' named entity 'IN VITRO' named entity 'ROLE' named entity 'INVESTIGATED' named entity 'c-Jun N-terminal kinase (JNK)' named entity 'response' named entity 'induces' named entity 'serogroup' named entity 'apoptosis' named entity 'family' named entity 'MAPK cascades' named entity 'MAPK' named entity 'apoptosis' named entity 'heat shock protein' named entity 'JNK' named entity 'p38 MAPK' named entity 'phosphorylated' named entity 'MAPK' named entity 'mitogen-activated protein kinase' named entity 'p38 MAPK' named entity 'genus' named entity 'Akabane virus' named entity 'JNK' named entity 'p38' named entity 'Akabane virus' named entity 'inhibitor' named entity 'c-Jun N-terminal kinase' named entity 'antibody'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software