About: Mesenchymal Stromal Cells and Exosomes: Progress and Challenges

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mesenchymal Stromal Cells and Exosomes: Progress and Challenges
Creator	Capitini, Christian Forsberg, Matthew Hematti, Peiman Kink, John Baldini, Nicola Van Den Beucken, Jeroen
Source	Medline; PMC
abstract	Due to their robust immunomodulatory capabilities, mesenchymal stem/stromal cells (MSCs) have been used as a cellular therapy for a number of human diseases. Part of the mechanism of action of MSCs is the production of extracellular vesicles (EVs) that contain proteins, nucleic acids, and lipids that transmit signals to recipient cells that change their biologic behavior. This review briefly summarizes the development of MSCs as a treatment for human diseases as well as describes our present understanding of exosomes; how they exert their effects on target cells, and how they are differentiated from other EVs. The current treatment paradigm for acute radiation syndrome (ARS) is discussed, and how MSCs and MSC derived exosomes are emerging as treatment options for treating patients after radiation exposure. Other conditions such as graft-versus-host disease and cardiovascular disease/stroke are discussed as examples to highlight the immunomodulatory and regenerative capacity of MSC-exosomes. Finally, a consideration is given to how these cell-based therapies could possibly be deployed in the event of a catastrophic radiation exposure event.
has issue date	2020-07-17(xsd:dateTime)
bibo:doi	10.3389/fcell.2020.00665
bibo:pmid	32766255
has license	cc-by
sha1sum (hex)	7e42df4651cea8d8f25f1c49e331b478389ef238
schema:url	https://doi.org/10.3389/fcell.2020.00665
resource representing a document's title	Mesenchymal Stromal Cells and Exosomes: Progress and Challenges
has PubMed Central identifier	PMC7379234
has PubMed identifier	32766255
schema:publication	Front Cell Dev Biol
resource representing a document's body	covid:7e42df4651cea8d8f25f1c49e331b478389ef238#body_text
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