About: Type I Interferon Receptor Signaling of Neurons and Astrocytes Regulates Microglia Activation during Viral Encephalitis

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About: Type I Interferon Receptor Signaling of Neurons and Astrocytes Regulates Microglia Activation during Viral Encephalitis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Type I Interferon Receptor Signaling of Neurons and Astrocytes Regulates Microglia Activation during Viral Encephalitis
Creator	Prinz, Marco Klein, Michael Borst, Katharina Bradke, Frank Chhatbar, Chintan Ghita, Luca Grabski, Elena Gudi, Viktoria Kalinke, Ulrich Mueller, Nora Spanier, Julia Stangel, Martin Sutton, James Correspondence, Ulrich Detje, Claudia Elliott, David Joana, Marta Jordão, Costa Prajeeth, Chittappen
Source	Elsevier; Medline; PMC
abstract	In sterile neuroinflammation, a pathological role is proposed for microglia, whereas in viral encephalitis, their function is not entirely clear. Many viruses exploit the odorant system and enter the CNS via the olfactory bulb (OB). Upon intranasal vesicular stomatitis virus instillation, we show an accumulation of activated microglia and monocytes in the OB. Depletion of microglia during encephalitis results in enhanced virus spread and increased lethality. Activation, proliferation, and accumulation of microglia are regulated by type I IFN receptor signaling of neurons and astrocytes, but not of microglia. Morphological analysis of myeloid cells shows that type I IFN receptor signaling of neurons has a stronger impact on the activation of myeloid cells than of astrocytes. Thus, in the infected CNS, the cross talk among neurons, astrocytes, and microglia is critical for full microglia activation and protection from lethal encephalitis.
has issue date	2018-10-02(xsd:dateTime)
bibo:doi	10.1016/j.celrep.2018.09.003
bibo:pmid	30282022
has license	no-cc
sha1sum (hex)	7de7583179a339a9eaa926656021735b0c9c84ce
schema:url	https://doi.org/10.1016/j.celrep.2018.09.003
resource representing a document's title	Type I Interferon Receptor Signaling of Neurons and Astrocytes Regulates Microglia Activation during Viral Encephalitis
has PubMed Central identifier	PMC7103936
has PubMed identifier	30282022
schema:publication	Cell Rep
resource representing a document's body	covid:7de7583179a339a9eaa926656021735b0c9c84ce#body_text
is schema:about of	covid:arg/7de7583179a339a9eaa926656021735b0c9c84ce named entity 'astrocytes' named entity 'olfactory' named entity 'neurons' named entity 'olfactory bulb' named entity 'microglia' named entity 'microglia' named entity 'Microglia' named entity 'Viral Encephalitis' named entity 'Neurons' named entity 'Receptor' named entity 'Astrocytes' named entity 'Microglia' named entity 'Astrocytes' named entity 'Type I Interferon' named entity 'astrocytes' named entity 'VSV' named entity 'VSV' named entity 'ER+' named entity 'neurotropic' named entity 'microglia' named entity 'microglia' named entity 'neuron' named entity 'CD45' named entity 'microglia' named entity 'myeloid cell' named entity 'monocytes' named entity 'BrdU' named entity 'IFNAR' named entity 'VSV' named entity 'astrocytes' named entity 'homeostasis' named entity 'abortively' named entity 'viral encephalitis' named entity 'microglia' named entity 'IFNAR' named entity 'VSV' named entity 'morphology' named entity 'microglia' named entity 'IFNAR' named entity 'Becton Dickinson' named entity 'P2ry12' named entity 'VSV' named entity 'mice' named entity 'monocytes' named entity 'virus' named entity 'mice' named entity 'VSV' named entity 'microglia' named entity 'IFNAR' named entity 'Ultramicroscope' named entity 'plasma membrane' named entity 'IgG' named entity 'PBS' named entity 'myeloid cell' named entity 'reporter mice' named entity 'myeloid cell' named entity 'CD45' named entity 'CD45' named entity 'VSV' named entity 'microglia' named entity 'Hexb' named entity 'IFNAR'

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