About: Ocular conjunctival inoculation of SARS-CoV-2 can cause mild COVID-19 in Rhesus macaques

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About: Ocular conjunctival inoculation of SARS-CoV-2 can cause mild COVID-19 in Rhesus macaques Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Ocular conjunctival inoculation of SARS-CoV-2 can cause mild COVID-19 in Rhesus macaques
Creator	Linlin, Bao Liu, Jiangning Qin, Chuan Xu, Yanfeng Gao, Hong Lv, Qi Liu, Xing Wei, Qiang Xue, Jing Xiao, Chong Deng, Wei Yu, Pin Han, Yunlin Qu, Yajin Song, Zhiqi Zhao, Wenjie Xiang, Zhiguang Liu, Jiayi Liu, Mingya Qi, Feifei Wang, Guanpeng Wang, Shunyi Yu, Haisheng Fengli, Gong, Shunran
source	BioRxiv
abstract	The outbreak of Corona Virus Disease 2019 caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2) is highly transmitted. The potential extra-respiratory transmission routes remain uncertain. Five rhesus macaques were inoculated with 1×106 TCID50 of SARS-CoV-2 via conjunctival (CJ), intratracheal (IT), and intragastric (IG) routes, respectively. Remarkably, the CJ inoculated-macaques developed mild interstitial pneumonia and viral load was detectable in the conjunctival swabs at 1 days post-inoculation (dpi). Only via IT inoculation, viral load was detected in the anal swab at 1-7 dpi and macaque showed weight loss. However, viral load was undetectable after IG inoculation. Comparatively, viral load was higher in the nasolacrimal system but lesions of lung were relatively mild and local via CJ inoculation compared with that via IT inoculation, demonstrating distinct characteristics of virus dispersion. Both the two routes affected the alimentary tract. Therefore the clinicians need to protect eye while working with patients.
has issue date	2020-03-30(xsd:dateTime)
bibo:doi	10.1101/2020.03.13.990036
has license	biorxiv
sha1sum (hex)	7dd4ed1de7d608c7c84d3ca6d95f9caf3d9a39aa
schema:url	https://doi.org/10.1101/2020.03.13.990036
resource representing a document's title	Ocular conjunctival inoculation of SARS-CoV-2 can cause mild COVID-19 in Rhesus macaques
schema:publication	bioRxiv
resource representing a document's body	covid:7dd4ed1de7d608c7c84d3ca6d95f9caf3d9a39aa#body_text
is schema:about of	named entity 'COVID-19' named entity 'UNCERTAIN' named entity 'ROUTES' named entity 'TRANSMITTED' named entity 'POTENTIAL' named entity 'Corona Virus Disease' named entity 'SARS-CoV-2' named entity 'COVID' named entity 'Rhesus macaques' named entity 'Five' named entity 'inoculation' named entity 'weight loss' named entity 'macaques' named entity 'excretory' named entity 'IT-1' named entity 'intratracheal' named entity 'palate' named entity 'RNA' named entity 'RNA' named entity 'RNA' named entity 'inoculation' named entity 'IgG antibody' named entity 'viral load' named entity 'macaques' named entity 'macaques' named entity 'viral load' named entity 'nasolacrimal' named entity 'duodenum' named entity 'Welch's t-test' named entity 'RNA' named entity 'RNA' named entity 'viral load' named entity 'macaques' named entity 'inoculation' named entity 'RNA' named entity 'macaque' named entity 'inoculation' named entity 'inoculation' named entity 'viral load' named entity 'inoculation' named entity 'macaque' named entity 'TCID50' named entity 'conjunctiva' named entity 'respiratory tract' named entity 'IT-1' named entity '1.03' named entity 'IT-1' named entity 'SARS-CoV-2' named entity '1.08' named entity 'blue color' named entity 'RNA' named entity 'lacrimal gland' named entity '1.06' named entity 'RNA' named entity 'macaques' named entity 'virus' named entity 'RNA' named entity 'RNA' named entity 'conjunctival' named entity 'macaque'

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