About: Developmental Regulation of Angiotensinogen Gene Expression in Sheep

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Developmental Regulation of Angiotensinogen Gene Expression in Sheep
Creator	Perlman, Stanley Olson, Ann Robillard, Jean
Source	PMC
abstract	ABSTRACT: It has been suggested that the liver is not the main source of angiotensinogen during fetal life in rats, but that the kidney is an important site of fetal angiotensinogen synthesis. In an effort to determine if this phenomenon is specific to the rat or applicable to other species, we compared the ontogenic changes in hepatic and renal angiotensinogen mRNA expression in fetal (60, 90, 118, and 138 d of gestation, term being 145 d), newborn (7 d postnatal), and adult sheep. Total RNA was extracted, subjected to Northern blotting and hybridized using a full-length rat radiolabeled antisense RNA. Angiotensinogen mRNA sequences were detected in all fetal liver samples and appeared to increase 3-fold from 60 to 138 d gestation and then to decrease after birth. In contrast, angiotensiogen mRNA could not be detected in renal cortical tissue of 118 or 138 d fetuses, or newborn or adult sheep. We conclude that, unlike in the rat, liver angiotensinogen gene expression is detectable during the 2nd trimester of gestation in sheep and is developmentally regulated. Furthermore, in contrast to the fetal rat, angiotensinogen mRNA sequences were undetectable in fetal sheep kidney.
has issue date	1990-01-01(xsd:dateTime)
bibo:doi	10.1203/00006450-199009000-00001
bibo:pmid	2235111
has license	no-cc
sha1sum (hex)	7d9b16764bee617ddc4ce0a17a257c22204411a2
schema:url	https://doi.org/10.1203/00006450-199009000-00001
resource representing a document's title	Developmental Regulation of Angiotensinogen Gene Expression in Sheep
has PubMed Central identifier	PMC7086511
has PubMed identifier	2235111
schema:publication	Pediatr Res
resource representing a document's body	covid:7d9b16764bee617ddc4ce0a17a257c22204411a2#body_text
is schema:about of	named entity 'mRNA' named entity 'sequences' named entity 'liver' named entity 'newborn' named entity 'adult' named entity 'USING' named entity 'TISSUE' named entity 'SHEEP' named entity 'CONTRAST' named entity 'angiotensinogen' named entity 'angiotensinogen' named entity 'kidney' named entity 'rats' named entity 'mRNA' named entity 'cortical tissue' named entity 'fetal' named entity 'kidney' named entity 'liver' named entity 'ontogenic' named entity 'Northern blotting' named entity 'radiolabeled' named entity 'SSPE' named entity 'sheep' named entity 'postnatal' named entity 'sheep' named entity 'kidney' named entity 'mRNA' named entity 'Northern blot' named entity 'rat' named entity 'gestation' named entity 'Northern blot' named entity 'ethanol' named entity 'centrifugation' named entity 'Fullerton, CA' named entity 'kidney' named entity 'gestation' named entity 'rat' named entity 'fetal liver' named entity 'ontogenic' named entity 'subcloned' named entity 'actin' named entity 'kidney' named entity 'Northern blot' named entity 'chloroform' named entity 'hepatic' named entity 'angiotensinogen' named entity 'RNA' named entity 'RNA' named entity 'RNA' named entity 'EcoRI' named entity 'angiotensinogen' named entity 'kidney' named entity 'angiotensinogen' named entity 'plasma' named entity '0.45' named entity 'RNA' named entity 'absorbance' named entity 'rat' named entity 'mRNA expression' named entity 'liver' named entity 'transcription' named entity 'kidney cortex' named entity '32P' named entity 'rat' named entity 'fetal' named entity 'RNA' named entity 'plasma levels' named entity 'mRNA' named entity 'EcoRI' named entity 'mRNA' named entity 'mRNA' named entity 'spectrophotometrically' named entity 'liver' named entity 'gene expression' named entity 'actin' named entity 'nitrous oxide' named entity 'fetal' named entity 'liver' named entity 'fetal'

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