About: Bacteraemia during the aplastic phase after allogeneic bone marrow transplantation is associated with early death from invasive fungal infection

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About: Bacteraemia during the aplastic phase after allogeneic bone marrow transplantation is associated with early death from invasive fungal infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Bacteraemia during the aplastic phase after allogeneic bone marrow transplantation is associated with early death from invasive fungal infection
Creator	Andersson, J Hägglund, H Ljungman, P Lönnqvist, B Remberger, M Ringdén, O Sparrelid, E
Source	PMC
abstract	Episodes of bacteraemia during the aplastic phase were studied in 500 allogeneic bone marrow (BMT) recipients, regarding incidence, microbial aetiology, risk factors, mortality and causes of death. One hundred and sixty-four patients (33%) had at least one positive blood culture. Gram-positive cocci (α-streptococci and coagulase-negative staphylococci) were found in 146/164 cases (89%). Gram-negative bacteria were present in only seven cases. Receiving marrow from an unrelated donor was the only significant risk factor for bacteraemia in univariate regression analysis. Within 60 days after BMT, 69/500 patients died. The mortality rate was significantly higher among those with positive blood cultures during the aplastic phase, 44/164 (27%) than in those without bacteraemia, 25/336 (7%). Death directly caused by sepsis was unusual in patients with α-streptococci or CNS-bacteraemia (8/146, 5%). In contrast, three of seven patients with gram-negative bacteraemia died of the infection. However, in patients with bacteraemia, 21 of 44 deaths were attributable to invasive fungal infections (18 candida, three aspergillus; autopsy findings). Among patients with negative blood cultures during the aplastic phase, 6/25 died of invasive fungal infection (three candida, one saccaromyces and two aspergillus). This indicates that early bacteraemia is associated with death from invasive fungal infection. Therefore, efforts to shorten the neutropenic period after BMT, prevention, early detection of invasive fungal infections and adjustments of immnosuppressive regimens when marrow from an unrelated donor is used, may improve the outcome after BMT.
has issue date	1998-10-09(xsd:dateTime)
bibo:doi	10.1038/sj.bmt.1701404
bibo:pmid	9827978
has license	no-cc
sha1sum (hex)	7d79eb94800ad0dcfb05f3bf9b7af0f43209f3e7
schema:url	https://doi.org/10.1038/sj.bmt.1701404
resource representing a document's title	Bacteraemia during the aplastic phase after allogeneic bone marrow transplantation is associated with early death from invasive fungal infection
has PubMed Central identifier	PMC7091628
has PubMed identifier	9827978
schema:publication	Bone Marrow Transplant
resource representing a document's body	covid:7d79eb94800ad0dcfb05f3bf9b7af0f43209f3e7#body_text
is schema:about of	named entity 'fungal infections' named entity 'cases' named entity 'blood cultures' named entity 'bacteraemia' named entity 'studied' named entity 'fungal infection' named entity 'allogeneic bone marrow transplantation' named entity 'CAUSES OF DEATH' named entity 'DIED' named entity 'FINDINGS' named entity 'REGIMENS' named entity 'ATTRIBUTABLE' named entity 'REGRESSION ANALYSIS' named entity 'PERIOD' named entity 'streptococci' named entity 'early' named entity 'invasive' named entity 'neutropenic' named entity 'patients' named entity 'phase' named entity 'fungal infections' named entity 'Gram-positive cocci' named entity 'bacteraemia' named entity 'blood culture' named entity 'blood cultures' named entity 'fungal infections' named entity 'candida' named entity 'fungal infection' named entity 'aspergillus' named entity 'Gram-negative bacteria' named entity 'CNS' named entity 'bacteraemia' named entity 'streptococci' named entity 'candida' named entity 'early death' named entity 'candida' named entity 'regression analysis' named entity 'bacteraemia' named entity 'bacteraemia' named entity 'bacteraemia' named entity 'bacteraemia' named entity 'autopsy' named entity 'fungal infection' named entity 'BMT' named entity 'died' named entity 'allogeneic' named entity 'aetiology' named entity '288' named entity 'INVASIVE FUNGAL INFECTIONS' named entity 'INVASIVE FUNGAL INFECTION' named entity 'MORTALITY RATE' named entity '90%' named entity 'PREVENTION' named entity 'sepsis' named entity 'aspergillus' named entity 'bacteraemia' named entity 'bone marrow' named entity 'mortality rate' named entity 'gram-negative' named entity 'streptococci' named entity 'fungal infection' named entity 'risk factor' named entity 'neutropenic' named entity 'FOUND' named entity 'RISK FACTORS' named entity 'POSITIVE' named entity 'blood cultures' named entity 'risk factors' named entity 'coagulase-negative staphylococci' covid:arg/7d79eb94800ad0dcfb05f3bf9b7af0f43209f3e7 named entity 'fungal infections' named entity 'HIGHER' named entity 'BONE MARROW' named entity 'PATIENTS' named entity 'APLASTIC'

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