About: Visceral fat shows the strongest association with the need of intensive Care in Patients with COVID-19

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About: Visceral fat shows the strongest association with the need of intensive Care in Patients with COVID-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Visceral fat shows the strongest association with the need of intensive Care in Patients with COVID-19
Creator	Watanabe, Mikiko Caruso, Damiano Laghi, Andrea Manfrini, Silvia Tuccinardi, Dario Gnessi, Lucio Lubrano, Carla Risi, Renata Polici, Michela Pucciarelli, Francesco Zerunian, Marta Basciani, Sabrina Mariani, Stefania Strigari, Lidia Tarallo, Mariarita
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: Obesity was recently identified as a major risk factor for worse COVID-19 severity, especially among the young. The reason why its impact seems to be less pronounced in the elderly may be due to the concomitant presence of other comorbidities. However, all reports only focus on BMI, an indirect marker of body fat. Aim To explore the impact on COVID-19 severity of abdominal fat as a marker of body composition easily collected in patients undergoing a chest CT scan. METHODS: Patients included in this retrospective study were consecutively enrolled among those admitted to an Emergency Department in Rome, Italy, who tested positive for SARS-Cov-2 and underwent a chest CT scan in March 2020. Data were extracted from electronic medical records. RESULTS: 150 patients were included (64.7% male, mean age 64 ± 16 years). Visceral fat (VAT) was significantly higher in patients requiring intensive care (p = .032), together with age (p = .009), inflammation markers CRP and LDH (p < .0001, p = .003, respectively), and interstitial pneumonia severity as assessed by a Lung Severity Score (LSS) (p < .0001). Increasing age, lymphocytes, CRP, LDH, D-Dimer, LSS, total abdominal fat as well as VAT were found to have a significant univariate association with the need of intensive care. A multivariate analysis showed that LSS and VAT were independently associated with the need of intensive care (OR: 1.262; 95%CI: 1.0171–1.488; p = .005 and OR: 2.474; 95%CI: 1.017–6.019; p = .046, respectively). CONCLUSIONS: VAT is a marker of worse clinical outcomes in patients with COVID-19. Given the exploratory nature of our study, further investigation is needed to confirm our findings and elucidate the mechanisms underlying such association.
has issue date	2020-07-23(xsd:dateTime)
bibo:doi	10.1016/j.metabol.2020.154319
bibo:pmid	32712222
has license	no-cc
sha1sum (hex)	7d457c3c6b3b43b85285d083a52419a59fc18bd9
schema:url	https://doi.org/10.1016/j.metabol.2020.154319
resource representing a document's title	Visceral fat shows the strongest association with the need of intensive Care in Patients with COVID-19
has PubMed Central identifier	PMC7377788
has PubMed identifier	32712222
schema:publication	Metabolism
resource representing a document's body	covid:7d457c3c6b3b43b85285d083a52419a59fc18bd9#body_text
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