About: Next Generation Sequencing of T and B cell receptor repertoires from COVID-19 patients showed signatures associated with severity of disease

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About: Next Generation Sequencing of T and B cell receptor repertoires from COVID-19 patients showed signatures associated with severity of disease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Next Generation Sequencing of T and B cell receptor repertoires from COVID-19 patients showed signatures associated with severity of disease
Creator	Ciesek, Sandra Addo, Marylyn Dahlke, Christine Binder, Mascha Addo, S Ciesek, D Dahlke, R Mohme, Malte Paschold, Lisa Scholz, L Scholz, Rebekka Schultheiß, C Schultheiß, Christoph Sedding, Daniel Simnica, Donjete Simnica, L Tolosa, C Tolosa, Eva Von Wenserski, Lisa Wenserski, Von Wieters, Imke Willscher, Edith
source	Elsevier; Medline; PMC
abstract	Summary We profiled adaptive immunity in COVID-19 patients with active infection or after recovery and created a repository of currently >14 million B and T cell receptor (BCR, TCR) sequences from blood of these patients. The B cell response showed converging IGHV3-driven BCR clusters closely associated with SARS-CoV-2 antibodies. Clonality and skewing of TCR repertoires was associated with interferon type I and III responses, early CD4+ and CD8+ T cell activation and counterregulation by the coreceptors BTLA, Tim-3, PD-1, TIGIT and CD73. Tfh, Th17-like and nonconventional (but not classical anti-viral) Th1 cell polarizations were induced. SARS-CoV-2-specific T cell responses were driven by TCR clusters shared between patients with a characteristic trajectory of clonotypes and traceability over the disease course. Our data provide fundamental insight into adaptive immunity to SARS-CoV-2 with the actively updated repository providing a resource for the scientific community urgently needed to inform therapeutic concepts and vaccine development.
has issue date	2020-06-30(xsd:dateTime)
bibo:doi	10.1016/j.immuni.2020.06.024
bibo:pmid	32668194
has license	els-covid
sha1sum (hex)	7cf5227987acfc03e547d7309a7aa0879ee520b9
schema:url	https://doi.org/10.1016/j.immuni.2020.06.024
resource representing a document's title	Next Generation Sequencing of T and B cell receptor repertoires from COVID-19 patients showed signatures associated with severity of disease
has PubMed Central identifier	PMC7324317
has PubMed identifier	32668194
schema:publication	Immunity
resource representing a document's body	covid:7cf5227987acfc03e547d7309a7aa0879ee520b9#body_text
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