About: Chemical screen identifies a geroprotective role of quercetin in premature aging

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About: Chemical screen identifies a geroprotective role of quercetin in premature aging Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Chemical screen identifies a geroprotective role of quercetin in premature aging
Creator	Wang, Wei Li, Wei Qu, Jing Sun, Liang Chan, Piu Geng, Lingling Ju, Zhenyu Liu, Guang-Hui Liu, Zunpeng Ren, Ruotong Song, Moshi Su, Yao Wang, Peichang Wu, Zeming Zhang, Weiqi
topic	covid:7cc4fbbb0881277449c41f6f408fab4fb9b907f5#this
source	PMC
abstract	Aging increases the risk of various diseases. The main goal of aging research is to find therapies that attenuate aging and alleviate aging-related diseases. In this study, we screened a natural product library for geroprotective compounds using Werner syndrome (WS) human mesenchymal stem cells (hMSCs), a premature aging model that we recently established. Ten candidate compounds were identified and quercetin was investigated in detail due to its leading effects. Mechanistic studies revealed that quercetin alleviated senescence via the enhancement of cell proliferation and restoration of heterochromatin architecture in WS hMSCs. RNA-sequencing analysis revealed the transcriptional commonalities and differences in the geroprotective effects by quercetin and Vitamin C. Besides WS hMSCs, quercetin also attenuated cellular senescence in Hutchinson-Gilford progeria syndrome (HGPS) and physiological-aging hMSCs. Taken together, our study identifies quercetin as a geroprotective agent against accelerated and natural aging in hMSCs, providing a potential therapeutic intervention for treating age-associated disorders. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13238-018-0567-y) contains supplementary material, which is available to authorized users.
has issue date	2018-08-01(xsd:dateTime)
bibo:doi	10.1007/s13238-018-0567-y
bibo:pmid	30069858
has license	cc-by
sha1sum (hex)	7cc4fbbb0881277449c41f6f408fab4fb9b907f5
schema:url	https://doi.org/10.1007/s13238-018-0567-y
resource representing a document's title	Chemical screen identifies a geroprotective role of quercetin in premature aging
has PubMed Central identifier	PMC6538594
has PubMed identifier	30069858
schema:publication	Protein Cell
resource representing a document's body	covid:7cc4fbbb0881277449c41f6f408fab4fb9b907f5#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/7cc4fbbb0881277449c41f6f408fab4fb9b907f5
is schema:about of	named entity 'human' named entity 'disorders' named entity 'quercetin' named entity 'attenuate' named entity 'progeria' named entity 'cell proliferation' named entity 'model' named entity 'revealed' named entity 'premature aging' named entity 'identifies' named entity 'PREMATURE AGING' covid:arg/7cc4fbbb0881277449c41f6f408fab4fb9b907f5 named entity 'HUTCHINSON-GILFORD PROGERIA SYNDROME' named entity 'PHYSIOLOGICAL' named entity 'CELL PROLIFERATION' named entity 'MESENCHYMAL STEM CELLS' named entity 'LEADING' named entity 'INCREASES' named entity 'AGING' named entity 'IDENTIFIED' named entity 'PROVIDING' named entity 'THERAPEUTIC INTERVENTION' named entity 'RELATED' named entity 'ACCELERATED' named entity 'EFFECTS' named entity 'CELLULAR SENESCENCE' named entity 'VITAMIN C' named entity 'CANDIDATE' named entity 'LIBRARY' named entity 'ATTENUATE' named entity 'ARCHITECTURE' named entity 'ATTENUATED' named entity 'THERAPIES' named entity 'MODEL' named entity 'AGE' named entity 'TRANSCRIPTIONAL' named entity 'SEQUENCING ANALYSIS' named entity 'VARIOUS' named entity 'USING' named entity 'RNA-SEQUENCING' named entity 'OUR' named entity 'RESEARCH' named entity 'MECHANISTIC STUDIES' named entity 'HUMAN' named entity 'SENESCENCE' named entity 'REVEALED' named entity 'MAIN' named entity 'ASSOCIATED DISORDERS' named entity 'AGENT' named entity 'RISK OF' named entity 'WERNER SYNDROME' named entity 'ESTABLISHED' named entity 'TREATING' named entity 'DUE TO' named entity 'POTENTIAL' named entity 'PREMATURE AGING' named entity 'NATURAL' named entity 'HETEROCHROMATIN' named entity 'GOAL' named entity 'INVESTIGATED' named entity 'CHEMICAL SCREEN' named entity 'ROLE' named entity 'QUERCETIN' named entity 'NATURAL PRODUCT' named entity 'RESTORATION'

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