About: Characterization of Eptesipoxvirus, a novel poxvirus from a microchiropteran bat

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About: Characterization of Eptesipoxvirus, a novel poxvirus from a microchiropteran bat Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Characterization of Eptesipoxvirus, a novel poxvirus from a microchiropteran bat
Creator	Upton, Chris Nakazawa, Yoshinori Wilkins, Kimberly Li, • Carroll, Darin Emerson, Ginny Gallardo-Romero, Nadia Gao, Jinxin Tu, Shin-Lin
Source	Medline; PMC
abstract	The genome of Eptesipoxvirus (EPTV) is the first poxvirus genome isolated from a microbat. The 176,688 nt sequence, which is believed to encompass the complete coding region of the virus, is 67% A+T and is predicted to encode 191 genes. 11 of these genes have no counterpart in GenBank and are therefore unique to EPTV. The presence of a distantly related ortholog of Vaccinia virus F5L in EPTV uncovered a link with fragmented F5L orthologs in Molluscum contagiosum virus/squirrelpox and clade II viruses. Consistent with the unique position of EPTV approximately mid-point between the orthopoxviruses and the clade II viruses, EPTV has 11 genes that are specific to the orthopoxviruses and 13 genes that are typical, if not exclusive, to the clade II poxviruses. This mosaic nature of EPTV blurs the distinction between the old description of the orthopoxvirus and clade II groups. Genome annotation and characterization failed to find any common virulence genes shared with the other poxvirus isolated from bat (pteropoxvirus); however, EPTV encodes 3 genes that may have been transferred to or from deerpox and squirrelpox viruses; 2 of these, a putative endothelin-like protein and a MHC class I-like protein are likely to have immunomodulatory roles. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11262-017-1485-4) contains supplementary material, which is available to authorized users.
has issue date	2017-07-06(xsd:dateTime)
bibo:doi	10.1007/s11262-017-1485-4
bibo:pmid	28685222
has license	no-cc
sha1sum (hex)	7c889771332aa0ced54beacf08a6f4de0a828760
schema:url	https://doi.org/10.1007/s11262-017-1485-4
resource representing a document's title	Characterization of Eptesipoxvirus, a novel poxvirus from a microchiropteran bat
has PubMed Central identifier	PMC6504846
has PubMed identifier	28685222
schema:publication	Virus Genes
resource representing a document's body	covid:7c889771332aa0ced54beacf08a6f4de0a828760#body_text
is schema:about of	named entity 'protein' named entity 'immunomodulatory' named entity 'fragmented' named entity 'complete' named entity 'GENES' covid:arg/7c889771332aa0ced54beacf08a6f4de0a828760 named entity 'virus' named entity 'EPTV' named entity 'orthopoxvirus' named entity 'viruses' named entity 'nature' named entity 'EPTV' named entity 'position' named entity 'shared' named entity 'Characterization' named entity 'orthopoxvirus' named entity 'viruses' named entity 'Vaccinia virus' named entity 'EPTV' named entity 'virus' named entity 'poxvirus' named entity 'coding region' named entity 'poxviruses' named entity 'EPTV' named entity 'microchiropteran' named entity 'Eptesicus fuscus' named entity 'clade' named entity 'reference genome' named entity 'EPTV' named entity 'nucleic acid' named entity 'EPTV' named entity 'orthopoxvirus' named entity 'pathogen' named entity 'Qiagen' named entity 'zoonotic disease' named entity 'rabies' named entity 'MSA' named entity 'orthopoxviruses' named entity 'orthopoxvirus' named entity 'orthopoxvirus' named entity 'viruses' named entity 'actin tail' named entity 'synteny' named entity 'EPTV' named entity 'viruses' named entity 'ORFs' named entity 'polypeptide' named entity 'membrane protein' named entity 'EPTV' named entity 'clade' named entity 'poxviruses' named entity 'big eyes' named entity 'hoofed mammals' named entity 'EPTV' named entity 'clade' named entity 'viruses' named entity 'poxviruses' named entity 'protein' named entity 'EPTV' named entity 'BLASTP' named entity 'EPTV' named entity 'GenBank' named entity 'orthologs' named entity 'A-type inclusion' named entity 'protein domains' named entity 'mis' named entity 'EPTV' named entity 'Chiroptera' named entity 'SAMtools' named entity 'protein' named entity 'genome sequence' named entity 'gene' named entity 'secondary structure prediction'

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