About: A hexapeptide of the receptor-binding domain of SARS corona virus spike protein blocks viral entry into host cells via the human receptor ACE2

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About: A hexapeptide of the receptor-binding domain of SARS corona virus spike protein blocks viral entry into host cells via the human receptor ACE2 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A hexapeptide of the receptor-binding domain of SARS corona virus spike protein blocks viral entry into host cells via the human receptor ACE2
Creator	Drosten, Christian Pfefferle, Susanne Axmann, Marco Meyer, Bernd Struck, Anna-Winona
Source	Elsevier; Medline; PMC
abstract	Abstract In vitro infection of Vero E6 cells by SARS coronavirus (SARS-CoV) is blocked by hexapeptide Tyr-Lys-Tyr-Arg-Tyr-Leu. The peptide also inhibits proliferation of coronavirus NL63. On human cells both viruses utilize angiotensin-converting enzyme 2 (ACE2) as entry receptor. Blocking the viral entry is specific as alpha virus Sindbis shows no reduction in infectivity. Peptide 438YKYRYL443 is part of the receptor-binding domain (RBD) of the spike protein of SARS-CoV. Peptide libraries were screened by surface plasmon resonance (SPR) to identify RBD binding epitopes. 438YKYRYL443 carries the dominant binding epitope and binds to ACE2 with K D =46μM. The binding mode was further characterized by saturation transfer difference (STD) NMR spectroscopy and molecular dynamic simulations. Based on this information the peptide can be used as lead structure to design potential entry inhibitors against SARS-CoV and related viruses.
has issue date	2012-06-30(xsd:dateTime)
bibo:doi	10.1016/j.antiviral.2011.12.012
bibo:pmid	22265858
has license	els-covid
sha1sum (hex)	7c6d538cfce58c60b243c2aba5290c379391ce9d
schema:url	https://doi.org/10.1016/j.antiviral.2011.12.012
resource representing a document's title	A hexapeptide of the receptor-binding domain of SARS corona virus spike protein blocks viral entry into host cells via the human receptor ACE2
has PubMed Central identifier	PMC7114193
has PubMed identifier	22265858
schema:publication	Antiviral Research
resource representing a document's body	covid:7c6d538cfce58c60b243c2aba5290c379391ce9d#body_text
is schema:about of	named entity 'RECEPTOR' named entity 'CORONA' named entity 'reduction' named entity 'Vero' named entity 'blocks' named entity 'PROTEIN ' named entity 'HOST CELLS' named entity 'VIRAL ENTRY' named entity 'RBD' named entity 'ANGIOTENSIN-CONVERTING ENZYME 2' named entity 'BLOCKED' named entity 'EPITOPES' named entity 'INFECTION' named entity 'TYR-ARG' named entity 'PEPTIDE LIBRARIES' named entity 'NO REDUCTION' named entity 'PEPTIDE' named entity '438' named entity 'PROLIFERATION' named entity 'DOMAIN' named entity 'ENTRY INHIBITORS' named entity 'DOMINANT' named entity 'SPIKE PROTEIN' named entity 'HEXAPEPTIDE' named entity 'VIRUSES' named entity 'SARS CORONAVIRUS' named entity 'CORONAVIRUS NL63' named entity 'PROTEIN ' named entity 'SARS-COV' named entity 'CHARACTERIZED' named entity 'TRANSFER' named entity 'ACE2' named entity 'ALPHA VIRUS' named entity 'HEXAPEPTIDE' named entity 'ENTRY INTO HOST' named entity 'VIRUS' named entity 'BINDING' named entity 'SPIKE PROTEIN' named entity 'HUMAN' named entity 'TYR-LYS' named entity 'TYR-LEU' named entity 'RECEPTOR' named entity 'ACE2' named entity 'USED' named entity 'BLOCKS' named entity 'DOMAIN' named entity 'CELLS' named entity 'BASED' named entity 'BLOCKING' named entity 'INFORMATION' named entity 'SARS' named entity 'ARG-TYR' named entity 'IN VITRO' named entity 'MODE' named entity 'SURFACE PLASMON RESONANCE' named entity 'DESIGN' named entity 'PART OF' named entity 'NMR SPECTROSCOPY' named entity 'EPITOPE' named entity 'RELATED' named entity 'CARRIES' named entity 'STRUCTURE' named entity 'VERO' named entity 'SINDBIS' named entity 'MOLECULAR DYNAMIC SIMULATIONS' named entity 'INFECTIVITY' named entity 'POTENTIAL' named entity 'VIRAL ENTRY' named entity 'LEAD' named entity 'SATURATION' named entity 'TO IDENTIFY' named entity 'HUMAN CELLS' named entity 'BINDING' named entity 'DIFFERENCE' named entity 'LYS-TYR' named entity 'ENTRY' named entity 'SPECIFIC'

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