About: Hepatitis E virus ORF1 encoded macro domain protein interacts with light chain subunit of human ferritin and inhibits its secretion

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About: Hepatitis E virus ORF1 encoded macro domain protein interacts with light chain subunit of human ferritin and inhibits its secretion Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Hepatitis E virus ORF1 encoded macro domain protein interacts with light chain subunit of human ferritin and inhibits its secretion
Creator	Kavita, • Kumar Ojha, Nishant Lole, S
Source	Medline; PMC
abstract	Hepatitis E Virus (HEV) is the major causative agent of acute hepatitis in developing countries. Its genome has three open reading frames (ORFs)—called as ORF1, ORF2, and ORF3. ORF1 encodes nonstructural polyprotein having multiple domains, namely: Methyltransferase, Y domain, Protease, Macro domain, Helicase, and RNA-dependent RNA polymerase. In the present study, we show that HEV-macro domain specifically interacts with light chain subunit of human ferritin (FTL). In cultured hepatoma cells, HEV-macro domain reduces secretion of ferritin without causing any change in the expression levels of FTL. This inhibitory effect was further enhanced upon Brefeldin-A treatment. The levels of transferrin Receptor 1 or ferroportin, two important proteins in iron metabolism, remained unchanged in HEV-macro domain expressing cells. Similarly, there were no alterations in the levels of cellular labile iron pool and reactive oxygen species, indicating that HEV-macro domain does not influence cellular iron homeostasis/metabolism. As ferritin is an acute-phase protein, secreted in higher level in infected persons and HEV-macro domain has the property of reducing synthesis of inflammatory cytokines, we propose that by directly binding to FTL, macro domain prevents ferritin from entering into circulation and helps in further attenuation of the host immune response. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11010-016-2715-0) contains supplementary material, which is available to authorized users.
has issue date	2016-05-12(xsd:dateTime)
bibo:doi	10.1007/s11010-016-2715-0
bibo:pmid	27170377
has license	no-cc
sha1sum (hex)	7aed633f807a46c2e5b23be0a37eb1dc28d15561
schema:url	https://doi.org/10.1007/s11010-016-2715-0
resource representing a document's title	Hepatitis E virus ORF1 encoded macro domain protein interacts with light chain subunit of human ferritin and inhibits its secretion
has PubMed Central identifier	PMC7089094
has PubMed identifier	27170377
schema:publication	Mol Cell Biochem
resource representing a document's body	covid:7aed633f807a46c2e5b23be0a37eb1dc28d15561#body_text
is schema:about of	named entity 'ORF1' named entity 'ITS' named entity 'SUBUNIT' named entity 'SECRETION' named entity 'MULTIPLE' named entity 'HEV' named entity 'MACRO' named entity 'FERRITIN' named entity 'METHYLTRANSFERASE' named entity 'INDICATING' named entity 'INFECTED' named entity 'LEVEL' named entity 'DIRECTLY' named entity 'PREVENTS' named entity 'REDUCING' named entity 'CAUSATIVE AGENT' named entity 'RNA-DEPENDENT RNA POLYMERASE' named entity 'ORF2' named entity 'ORF1' named entity 'HOST IMMUNE RESPONSE' named entity 'IRON METABOLISM' named entity 'ACUTE-PHASE PROTEIN' named entity 'LIGHT CHAIN' named entity 'FTL' named entity 'TRANSFERRIN RECEPTOR 1' named entity 'MACRO' named entity 'LEVELS' named entity 'BINDING' named entity 'HIGHER' named entity '2C HELICASE' named entity 'CYTOKINES' named entity 'DOMAIN' named entity 'SECRETED' named entity 'FERROPORTIN' named entity 'ATTENUATION' named entity 'ITS' named entity 'EXPRESSION' named entity 'REACTIVE OXYGEN SPECIES' named entity 'POOL' named entity 'HUMAN FERRITIN' named entity 'UNCHANGED' named entity 'STUDY' named entity 'GENOME' named entity 'INFLUENCE' named entity 'HEPATITIS E VIRUS' named entity 'IRON' named entity 'DEVELOPING COUNTRIES' named entity 'CULTURED' named entity 'SECRETION' named entity 'BREFELDIN' named entity 'ACUTE HEPATITIS' named entity 'ENCODED' named entity 'CELLULAR' named entity 'PERSONS' named entity 'HELPS' named entity 'PROTEIN ' named entity 'HEPATITIS E VIRUS' named entity 'LIGHT CHAIN' named entity 'HUMAN FERRITIN' named entity 'ORF3' named entity 'DOES NOT' named entity 'DOMAIN' named entity 'IRON HOMEOSTASIS' named entity 'PROTEASE' named entity 'HEPATOMA CELLS' named entity 'CIRCULATION' named entity 'INHIBITORY EFFECT' named entity 'MAJOR' named entity 'OPEN READING FRAMES' named entity 'ENHANCED' named entity 'CHANGE IN' named entity 'SUBUNIT' named entity 'INFLAMMATORY' named entity 'ALTERATIONS' named entity 'CAUSING' named entity 'CELLS' named entity 'PRESENT' named entity 'PROPERTY' named entity 'IMPORTANT'

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