About: NLRP3 Inflammasome Activation Is Essential for Paraquat-Induced Acute Lung Injury

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	NLRP3 Inflammasome Activation Is Essential for Paraquat-Induced Acute Lung Injury
Creator	Wang, Yu Liu, Wei Li, Tiegang Zhao, Min Zhao, Hongyu Liu, Zhenning
Source	PMC
abstract	The innate immune response is important in paraquat-induced acute lung injury, but the exact pathways involved are not elucidated. The objectives of this study were to determine the specific role of the NLRP3 inflammasome in the process. Acute lung injury was induced by administering paraquat (PQ) intraperitoneally. NLRP3 inflammasome including NLRP3, ASC, and caspase-1 mRNA and protein expression in lung tissue and IL-1β and IL-18 levels in BALF were detected at 4, 8, 24, and 72 h after PQ administration in rats. Moreover, rats were pretreated with 10, 30, and 50 mg/kg NLRP3 inflammasome blocker glybenclamide, respectively, 1 h before PQ exposure. At 72 h after PQ administration, lung histopathology changes, NLRP3, ASC, and caspase-1 protein expression, as well as secretion of cytokines including IL-1β and IL-18 in BALF were investigated. The NLRP3 inflammasome including NLRP3, ASC, caspase-1 expression, and cytokines IL-1β and IL-18 levels in PQ poisoning rats were significantly higher than that in the control group. NLRP3 inflammasome blocker glybenclamide pretreatment attenuated lung edema, inhibited the NLRP3, ASC, and caspase-1 activation, and reduced IL-1β and IL-18 levels in BALF. In the in vitro experiments, IL-1β and IL-18 secreted from RAW264.7 mouse macrophages treated with paraquat were attenuated by glybenclamide. In conclusion, paraquat can induce IL-1β/IL-18 secretion via NLRP3-ASC-caspase-1 pathway, and the NLRP3 inflammasome is essential for paraquat-induced acute lung injury.
has issue date	2014-10-23(xsd:dateTime)
bibo:doi	10.1007/s10753-014-0048-2
bibo:pmid	25338942
has license	no-cc
sha1sum (hex)	7ad8e5c9b51c3ae60013d0636c122d47f87efead
schema:url	https://doi.org/10.1007/s10753-014-0048-2
resource representing a document's title	NLRP3 Inflammasome Activation Is Essential for Paraquat-Induced Acute Lung Injury
has PubMed Central identifier	PMC7101550
has PubMed identifier	25338942
schema:publication	Inflammation
resource representing a document's body	covid:7ad8e5c9b51c3ae60013d0636c122d47f87efead#body_text
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