About: Variation in Active Site Amino Residues of H1N1 Swine Flu Neuraminidase

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Variation in Active Site Amino Residues of H1N1 Swine Flu Neuraminidase
Creator	Apparao, A Rama, T Rao, G Rao, Krishna Srinivasarao, P
Source	PMC
abstract	In this paper, we report the variations of amino acid residues between H5N1 and H1N1 swine flu neuraminidase sequences at protein level. Random search in NCBI Flu database resulted in Canadian viral gene and analysis using blast technique revealed sites that are variant among sequences for which 3-dimensional structures were known. PDB summary database and multiple alignments were employed for validation of the results. Based on the mutations observed within active site region, homology derived model was constructed using swiss-pdb viewer. The residue variation observed was with respect to Tyr347 in H5N1 versus Asn344 in H1N1 neuraminidase sequence, which resulted in geometrical modification of ligand binding domain.
has issue date	2012-01-01(xsd:dateTime)
bibo:doi	10.1007/978-81-322-0740-5_68
has license	no-cc
sha1sum (hex)	7acc0bbb9d54064cc7abad052dd0f0b482187dab
schema:url	https://doi.org/10.1007/978-81-322-0740-5_68
resource representing a document's title	Variation in Active Site Amino Residues of H1N1 Swine Flu Neuraminidase
has PubMed Central identifier	PMC7124146
schema:publication	Proceedings of International Conference on Advances in Computing
resource representing a document's body	covid:7acc0bbb9d54064cc7abad052dd0f0b482187dab#body_text
is schema:about of	named entity 'derived' named entity 'Flu' named entity 'geometrical' named entity 'database' named entity 'neuraminidase' named entity 'H1N1' named entity 'Site' named entity 'Amino' named entity 'PAPER' named entity 'REVEALED' named entity 'BASED' named entity 'SWINE FLU' named entity 'AMINO ACID' named entity 'STRUCTURES' named entity 'ANALYSIS' named entity 'SUMMARY' named entity 'VARIATION' named entity 'H5N1' named entity 'multiple' named entity 'PDB' named entity 'Canadian' named entity 'gene' named entity 'Flu' named entity '3D structure' named entity 'neuraminidase' named entity 'active site' named entity 'H1N1' named entity 'enzyme' named entity 'neuraminidase' named entity 'mutation' named entity 'general discomfort' named entity 'saliva' named entity 'neuraminidase' named entity 'H1N1' named entity 'bird flu' named entity 'influenza' named entity 'Trp' named entity 'influenza pandemic' named entity 'mammals' named entity 'Swine influenza' named entity 'computational tools' named entity 'H5N1' named entity 'H1N1' named entity 'glycoconjugates' named entity 'flu' named entity 'oseltamivir' named entity 'neuraminidase' named entity 'Conserved Domain' named entity 'nutrition' named entity 'pig' named entity 'virus' named entity 'gene' named entity 'neuraminidase' named entity 'NCBI' named entity 'influenza viruses' named entity 'nasal secretions' named entity 'H1N1' named entity 'H5N1' named entity 'faeces' named entity 'chills' named entity 'BLOSUM' named entity 'Asia' named entity 'Gly' named entity 'mutation' named entity 'NCBI' named entity 'human influenza' named entity 'fasta format' named entity 'muscle pains' named entity 'headache' named entity 'H1N1' named entity '3D structure' named entity 'transmitted through the air' named entity 'Neuraminidase' named entity 'hydrolyze' named entity 'infectious disease' named entity 'sore throat' named entity 'protein sequence' named entity 'avian flu' named entity 'Phe'

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