About: Single cell resolution regulatory landscape of the mouse kidney highlights cellular differentiation programs and renal disease targets

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About: Single cell resolution regulatory landscape of the mouse kidney highlights cellular differentiation programs and renal disease targets Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Single cell resolution regulatory landscape of the mouse kidney highlights cellular differentiation programs and renal disease targets
Creator	Liu, Hongbo Li, Mingyao Aranyi, Tamas Balzer, Michael Kaestner, Klaus Kim, Junhyong Kondo, Ayano Kwan, Amy Ma, Ziyuan Miao, Zhen Pontoglio, Marco Susztak, Katalin Wu, Junnan
Source	BioRxiv
abstract	Determining the epigenetic program that generates unique cell types in the kidney is critical for understanding cell-type heterogeneity during tissue homeostasis and injury response. Here, we profiled open chromatin and gene expression in developing and adult mouse kidneys at single cell resolution. We show critical reliance of gene expression on distal regulatory elements (enhancers). We define key cell type-specific transcription factors and major gene-regulatory circuits for kidney cells. Dynamic chromatin and expression changes during nephron progenitor differentiation demonstrated that podocyte commitment occurs early and is associated with sustained Foxl1 expression. Renal tubule cells followed a more complex differentiation, where Hfn4a was associated with proximal and Tfap2b with distal fate. Mapping single nucleotide variants associated with human kidney disease identified critical cell types, developmental stages, genes, and regulatory mechanisms. We provide a global single cell resolution view of chromatin accessibility of kidney development. The dataset is available via interactive public websites.
has issue date	2020-06-04(xsd:dateTime)
bibo:doi	10.1101/2020.05.24.113910
has license	biorxiv
sha1sum (hex)	7abe757f8c153c9ceee6e4418759ec73e9d9cea1
schema:url	https://doi.org/10.1101/2020.05.24.113910
resource representing a document's title	Single cell resolution regulatory landscape of the mouse kidney highlights cellular differentiation programs and renal disease targets
schema:publication	bioRxiv
resource representing a document's body	covid:7abe757f8c153c9ceee6e4418759ec73e9d9cea1#body_text
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