About: IL-12 RB1 Genetic Variants Contribute to Human Susceptibility to Severe Acute Respiratory Syndrome Infection among Chinese

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About: IL-12 RB1 Genetic Variants Contribute to Human Susceptibility to Severe Acute Respiratory Syndrome Infection among Chinese Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	IL-12 RB1 Genetic Variants Contribute to Human Susceptibility to Severe Acute Respiratory Syndrome Infection among Chinese
Creator	Cao, Wu-Chun Liu, Wei Ly, Hinh Yang, Hong Tang, Fang »more»
topic	covid:7a5478dfe79fbf67551ac9261f190d899ba719b3#this
source	Medline; PMC
abstract	BACKGROUND: Cytokines play important roles in antiviral action. We examined whether polymorphisms of interleukin (IL)-12 receptor B1 (IL-12RB1) affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS). METHODS: A case-control study was carried out in Chinese SARS patients and healthy controls. The genotypes of 4SNPs on IL-12 RB1 gene, +705A/G,+1158T/C, +1196G/C and +1664 C/T, were determined by PCR-RFLP. Haplotypes were estimated from the genotype data using the expectation-maximisation algorithm. RESULTS: Comparison between patients and close contacts showed that individuals with the +1664 C/T (CT and TT) genotype had a 2.09-fold (95% confidence interval [CI], 1.90–7.16) and 2.34-fold (95% CI, 1.79–13.37) increased risk of developing SARS, respectively. For any of the other three polymorphisms, however, no significant difference can be detected in allele or genotype frequencies between patients and controls. Additionally, estimation of the frequencies of multiple-locus haplotypes revealed potential risk haplotypes (GCCT) for SARS infection. CONCLUSIONS: Our data indicate that genetic variants of IL12RB1confer genetic susceptibility to SARS infection, but not necessary associated with the progression of the disease in Chinese population.
has issue date	2008-05-14(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0002183
bibo:pmid	18478121
has license	cc-by
sha1sum (hex)	7a5478dfe79fbf67551ac9261f190d899ba719b3
schema:url	https://doi.org/10.1371/journal.pone.0002183
resource representing a document's title	IL-12 RB1 Genetic Variants Contribute to Human Susceptibility to Severe Acute Respiratory Syndrome Infection among Chinese
has PubMed Central identifier	PMC2367437
has PubMed identifier	18478121
schema:publication	PLoS One
resource representing a document's body	covid:7a5478dfe79fbf67551ac9261f190d899ba719b3#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/7a5478dfe79fbf67551ac9261f190d899ba719b3
is schema:about of	covid:arg/7a5478dfe79fbf67551ac9261f190d899ba719b3 named entity 'CYTOKINES' named entity 'CONTRIBUTE ' named entity 'PLAY' named entity 'RECEPTOR' »more»

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