About: A 2a/1b full-length p7 inter-genotypic chimeric genome of hepatitis C virus is infectious in vitro

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About: A 2a/1b full-length p7 inter-genotypic chimeric genome of hepatitis C virus is infectious in vitro Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A 2a/1b full-length p7 inter-genotypic chimeric genome of hepatitis C virus is infectious in vitro
Creator	Bowden, S Dong, X Ewart, G Gowans, E Haqshenas, G
Source	Elsevier; Medline; PMC
abstract	Abstract The p7 protein of hepatitis C virus (HCV) functions as an ion channel in planar lipid bilayers, and its function is vital for the virus life cycle. In this study, we replaced either the entire or partial p7 of genotype 2a (strain JFH1), an HCV strain that replicates and produces virus progeny in vitro, with the corresponding regions of the p7 protein from genotype 1b (Australian isolate, HCV-A). Compared to wild type, the chimeric viruses reached their peak of infectivity with a delay but they produced a comparable titer to the wild type virus and the progeny viruses were able to infect naive permissive cells. Amantadine treatment of wild type and chimeric viruses reduced the virus titers by about 50% and 45%, respectively. Therefore, in this study, for the first time, we demonstrated that genotype 2a (JFH1 strain) genome encoding a full-length genotype 1b p7 gene produces infectious particles in vitro. These chimeric viruses are valuable instruments for comparative studies of the p7 proteins.
has issue date	2007-03-30(xsd:dateTime)
bibo:doi	10.1016/j.virol.2006.10.014
bibo:pmid	17097709
has license	els-covid
sha1sum (hex)	79d081da39e4c7399ceb62b3171514261a8d6e69
schema:url	https://doi.org/10.1016/j.virol.2006.10.014
resource representing a document's title	A 2a/1b full-length p7 inter-genotypic chimeric genome of hepatitis C virus is infectious in vitro
has PubMed Central identifier	PMC7103279
has PubMed identifier	17097709
schema:publication	Virology
resource representing a document's body	covid:79d081da39e4c7399ceb62b3171514261a8d6e69#body_text
is schema:about of	named entity 'GENOME' named entity 'strain' named entity 'study' named entity 'p7 protein' named entity 'viruses' named entity 'INTER-' named entity 'REDUCED' named entity 'PARTICLES' named entity 'STUDY' named entity 'PEAK' named entity 'THEIR' named entity 'DEMONSTRATED' named entity 'INFECTIOUS' named entity 'REPLICATES' named entity 'WILD TYPE' named entity 'IN VITRO' named entity 'VIRUS' named entity 'FUNCTION' named entity 'TITER' named entity 'PROTEIN ' named entity 'GENOTYPE 1B' named entity 'REGIONS' named entity 'ENTIRE' named entity 'GENOTYPE' named entity 'LIPID BILAYERS' named entity 'TO INFECT' named entity 'CHIMERIC' named entity 'LENGTH' named entity 'HEPATITIS C VIRUS' named entity 'HEPATITIS C VIRUS' named entity 'INFECTIOUS' named entity 'COMPARED' named entity 'ITS' named entity 'ABOUT' named entity 'INSTRUMENTS' named entity 'REPLACED' named entity 'GENOTYPIC' named entity 'CELLS' named entity 'GENE' named entity 'LIFE CYCLE' named entity 'STRAIN' named entity 'EITHER' named entity 'AMANTADINE' named entity 'BUT' named entity 'THESE' named entity 'ION CHANNEL' named entity 'LENGTH' named entity 'ISOLATE' named entity 'PROGENY' named entity 'PARTIAL' named entity 'FUNCTIONS' named entity 'PLANAR' named entity 'PROTEINS' named entity 'TREATMENT' named entity 'COMPARATIVE STUDIES' named entity 'IN VITRO' named entity 'VITAL' named entity 'CHIMERIC' named entity 'TYPE VIRUS' named entity 'DELAY' named entity 'HCV' named entity 'INFECTIVITY' named entity 'TIME' named entity 'VIRUSES' named entity 'ENCODING' named entity '50%' named entity 'GENOME' covid:arg/79d081da39e4c7399ceb62b3171514261a8d6e69 named entity 'planar' named entity 'replicates' named entity 'virus' named entity 'produces' named entity 'titers' named entity 'comparable' named entity 'progeny' named entity 'vital' named entity 'genotype'

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