About: Optimal mean airway pressure during high-frequency oscillatory ventilation in an experimental model of acute respiratory distress syndrome: EIT-based method

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About: Optimal mean airway pressure during high-frequency oscillatory ventilation in an experimental model of acute respiratory distress syndrome: EIT-based method Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Optimal mean airway pressure during high-frequency oscillatory ventilation in an experimental model of acute respiratory distress syndrome: EIT-based method
Creator	Yang, Yi Qiu, Haibo Tan, Li Yu, Tao Huang, Yingzi Liu, Songqiao Möller, Knut Pan, Chun Wang, Lihui Frerichs, Inéz Zhao, Zhanqi
Source	PMC
abstract	BACKGROUND: High-frequency oscillatory ventilation (HFOV) may theoretically provide lung protective ventilation. The negative clinical results may be due to inadequate mean airway pressure (mPaw) settings in HFOV. Our objective was to evaluate the air distribution, ventilatory and hemodynamic effects of individual mPaw titration during HFOV in ARDS animal based on oxygenation and electrical impedance tomography (EIT). METHODS: ARDS was introduced with repeated bronchoalveolar lavage followed by injurious mechanical ventilation in ten healthy male pigs (51.2 ± 1.9 kg). Settings of HFOV were 9 Hz (respiratory frequency), 33% (inspiratory time) and 70 cmH(2)O (∆pressure). After lung recruitment, the mPaw was reduced in steps of 3 cmH(2)O every 6 min. Hemodynamics and blood gases were obtained in each step. Regional ventilation distribution was determined with EIT. RESULTS: PaO(2)/FiO(2) decreased significantly during the mPaw decremental phase (p < 0.001). Lung overdistended regions decreased, while recruitable regions increased as mPaw decreased. The optimal mPaw with respect to PaO(2)/FiO(2) was 21 (18.0–21.0) cmH(2)O, that is comparable to EIT-based center of ventilation (EIT-CoV) and EIT-collapse/over, 19.5 (15.0–21.0) and 19.5 (18.0–21.8), respectively (p = 0.07). EIT-CoV decreasing along with mPaw decrease revealed redistribution toward non-dependent regions. The individual mPaw titrated by EIT-based indices improved regional ventilation distribution with respect to overdistension and collapse (p = 0.035). CONCLUSION: Our data suggested personalized optimal mPaw titration by EIT-based indices improves regional ventilation distribution and lung homogeneity during high-frequency oscillatory ventilation.
has issue date	2020-03-06(xsd:dateTime)
bibo:doi	10.1186/s13613-020-0647-z
bibo:pmid	32144514
has license	cc-by
sha1sum (hex)	7940c11a158fe6c858664a4e72cf219c3d541c2c
schema:url	https://doi.org/10.1186/s13613-020-0647-z
resource representing a document's title	Optimal mean airway pressure during high-frequency oscillatory ventilation in an experimental model of acute respiratory distress syndrome: EIT-based method
has PubMed Central identifier	PMC7060304
has PubMed identifier	32144514
schema:publication	Ann Intensive Care
resource representing a document's body	covid:7940c11a158fe6c858664a4e72cf219c3d541c2c#body_text
is schema:about of	named entity 'titration' named entity 'experimental' named entity 'BASED' named entity 'NEGATIVE' named entity 'BACKGROUND' covid:arg/7940c11a158fe6c858664a4e72cf219c3d541c2c named entity 'EIT' named entity 'Our' named entity 'lung' named entity 'provide' named entity 'distribution' named entity 'high-frequency oscillatory ventilation' named entity 'Electrical impedance tomography' named entity 'ICU' named entity 'CVP' named entity 'interquartile range' named entity 'ARDS' named entity 'catheter' named entity 'EIT' named entity 'meta-analysis' named entity 'mechanical ventilation' named entity 'PCV' named entity 'positive end-expiratory pressure' named entity 'HFOV' named entity 'titration' named entity 'thorax' named entity 'impedance' named entity 'ARDS' named entity 'clinic setting' named entity 'body weight' named entity 'EIT' named entity 'citrate' named entity 'airway' named entity 'electrolyte' named entity 'ARDS' named entity 'chronic obstructive pulmonary disease' named entity 'pig' named entity 'Reading, PA' named entity 'internal jugular vein' named entity 'HFOV' named entity 'titration' named entity 'firstline' named entity 'EIT' named entity 'PEEP' named entity 'High-frequency oscillatory ventilation' named entity 'Solna' named entity 'endothelial' named entity 'finite element method' named entity 'HFOV' named entity 'MAP' named entity 'EIT' named entity 'lung' named entity 'atracurium' named entity 'EIT' named entity 'computed tomography' named entity 'Southeast University' named entity 'clinician' named entity 'EIT' named entity 'animal studies' named entity 'Sweden' named entity 'isotonic saline' named entity 'Newton-Raphson' named entity 'CMV' named entity 'EIT' named entity 'impedance' named entity 'partial pressure of arterial oxygen' named entity 'ARDS' named entity 'lung' named entity 'HFOV' named entity 'lung' named entity 'prone position'

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