About: Genotype and phenotype of COVID-19: Their roles in pathogenesis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Genotype and phenotype of COVID-19: Their roles in pathogenesis
Creator	Ghasemi, Sorayya Mousavizadeh, Leila
Source	Elsevier; Medline; PMC
abstract	Abstract COVID-19 is a novel coronavirus with an outbreak of unusual viral pneumonia in Wuhan, China, and then pandemic. Based on its phylogenetic relationships and genomic structures the COVID-19 belongs to genera Betacoronavirus. Human Betacoronaviruses (SARS-CoV-2, SARS-CoV, and MERS-CoV) have many similarities, but also have differences in their genomic and phenotypic structure that can influence their pathogenesis. COVID-19 is containing single-stranded (positive-sense) RNA associated with a nucleoprotein within a capsid comprised of matrix protein. A typical CoV contains at least six ORFs in its genome. All the structural and accessory proteins are translated from the sgRNAs of CoVs. Four main structural proteins are encoded by ORFs 10, 11 on the one-third of the genome near the 3′-terminus. The genetic and phenotypic structure of COVID-19 in pathogenesis is important. This article highlights the most important of these features compared to other Betacoronaviruses.
has issue date	2020-03-31(xsd:dateTime)
bibo:doi	10.1016/j.jmii.2020.03.022
bibo:pmid	32265180
has license	els-covid
sha1sum (hex)	78ea5fa9437b7e90314416f066a38ad9b2d6e4cf
schema:url	https://doi.org/10.1016/j.jmii.2020.03.022
resource representing a document's title	Genotype and phenotype of COVID-19: Their roles in pathogenesis
has PubMed Central identifier	PMC7138183
has PubMed identifier	32265180
schema:publication	J Microbiol Immunol Infect
resource representing a document's body	covid:78ea5fa9437b7e90314416f066a38ad9b2d6e4cf#body_text
is schema:about of	named entity 'PATHOGENESIS' named entity 'All' named entity 'TYPICAL' named entity 'RNA' named entity 'SENSE' named entity 'COMPARED' named entity 'NEAR' named entity '10%' named entity 'CONTAINING' named entity 'UNUSUAL' named entity 'ASSOCIATED WITH' named entity 'GENOMIC' named entity 'KEYWORDS' named entity 'THEIR' named entity 'ITS' named entity 'FEATURES' named entity 'BASED' named entity 'GENOTYPE AND PHENOTYPE' named entity 'COVID-19' named entity 'ROLES' named entity 'COVID-19' named entity 'GENOME' named entity 'COVS' named entity 'VIRAL PNEUMONIA' named entity 'MATRIX PROTEIN' named entity 'ACCESSORY' named entity 'NUCLEOPROTEIN' named entity 'THEIR' named entity 'GENETIC' named entity 'WUHAN' named entity 'CHINA' named entity 'ENCODED' named entity 'STRUCTURAL' named entity 'IS A' named entity 'TERMINUS' named entity 'PANDEMIC' named entity 'STRUCTURES' named entity 'TRANSLATED' named entity 'OUTBREAK' named entity 'BETACORONAVIRUS' named entity 'STRUCTURE' named entity 'IMPORTANT' named entity 'MERS-COV' named entity 'ORFS' named entity 'MAIN' named entity 'HAVE' named entity 'ARTICLE' named entity 'INFLUENCE' named entity 'STRUCTURAL PROTEINS' named entity 'CAPSID' named entity 'THESE' named entity 'PATHOGENESIS' named entity 'CONTAINS' named entity 'SARS-COV' named entity 'BUT' named entity 'HUMAN' named entity 'RELATIONSHIPS' named entity 'PROTEINS' named entity 'MERS-CoV' named entity 'translated' named entity 'similarities' named entity 'structures' named entity 'features' named entity 'structural proteins' named entity 'proteins' named entity 'phenotype' named entity 'Betacoronavirus' named entity 'viral pneumonia' named entity 'genome' named entity 'SARS-CoV' named entity 'pathogenesis' named entity 'COVID-19' named entity 'pathogenesis' named entity 'hepatic' named entity 'UTR' named entity 'subfamily' named entity 'structural proteins' named entity 'COVID-19' named entity 'gene' named entity 'coronavirus'

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