About: SARS‐CoV‐2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells

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About: SARS‐CoV‐2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	SARS‐CoV‐2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells
Creator	Boots, Agnes Kreuter, Michael Schneider, Marc Conrad, Christian Eils, Roland Hennig, Bianca Kahn, Nicolas Lukassen, Soeren Meister, Michael Muley, Thomas Trefzer, Timo Veith, Carmen Winter, Hauke Lorenz Chua, Robert
topic	covid:78c7ab1626fb6f72c09c280f8587f64ae7763d61#this
Source	Medline; PMC; WHO
abstract	The SARS‐CoV‐2 pandemic affecting the human respiratory system severely challenges public health and urgently demands for increasing our understanding of COVID‐19 pathogenesis, especially host factors facilitating virus infection and replication. SARS‐CoV‐2 was reported to enter cells via binding to ACE2, followed by its priming by TMPRSS2. Here, we investigate ACE2 and TMPRSS2 expression levels and their distribution across cell types in lung tissue (twelve donors, 39,778 cells) and in cells derived from subsegmental bronchial branches (four donors, 17,521 cells) by single nuclei and single cell RNA sequencing, respectively. While TMPRSS2 is strongly expressed in both tissues, in the subsegmental bronchial branches ACE2 is predominantly expressed in a transient secretory cell type. Interestingly, these transiently differentiating cells show an enrichment for pathways related to RHO GTPase function and viral processes suggesting increased vulnerability for SARS‐CoV‐2 infection. Our data provide a rich resource for future investigations of COVID‐19 infection and pathogenesis.
has issue date	2020-04-14(xsd:dateTime)
bibo:doi	10.15252/embj.20105114
bibo:pmid	32246845
has license	cc-by
sha1sum (hex)	78c7ab1626fb6f72c09c280f8587f64ae7763d61
schema:url	https://doi.org/10.15252/embj.20105114
resource representing a document's title	SARS‐CoV‐2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells
has PubMed Central identifier	PMC7232010
has PubMed identifier	32246845
schema:publication	EMBO J
resource representing a document's body	covid:78c7ab1626fb6f72c09c280f8587f64ae7763d61#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/78c7ab1626fb6f72c09c280f8587f64ae7763d61
is schema:about of	named entity 'cells' named entity 'cell types' named entity 'facilitating' named entity 'cells' named entity 'respiratory system' named entity 'PRIMING' named entity 'RESOURCE' named entity 'TRANSIENT' named entity 'SINGLE' named entity 'REPORTED' named entity 'BINDING' named entity 'REPLICATION' named entity 'RESPIRATORY SYSTEM' named entity 'VULNERABILITY' named entity 'RHO GTPASE' named entity 'HUMAN' named entity 'LEVELS' named entity 'PUBLIC HEALTH' named entity 'INCREASING' named entity 'DEMANDS' covid:arg/78c7ab1626fb6f72c09c280f8587f64ae7763d61 named entity 'pandemic' named entity 'expressed' named entity 'vulnerability' named entity 'TMPRSS2' named entity 'enter' named entity 'rich' named entity 'function' named entity 'SARS-CoV-2' named entity 'expression' named entity 'branches' named entity 'infection' named entity 'COVID' named entity 'ACE2' named entity 'infection' named entity 'single cell RNA sequencing' named entity 'TMPRSS2' named entity 'SARS-CoV-2 pandemic' named entity 'virus infection' named entity 'infection' named entity 'pathogenesis' named entity 'TMPRSS2' named entity 'infection' named entity 'liquid nitrogen' named entity 'epithelia' named entity 'FURIN' named entity 'ethics committee' named entity 'protein' named entity 'DTT' named entity 'SARS-CoV-2' named entity 'FURIN' named entity 'Wilcoxon rank sum test' named entity 'smokers' named entity 'SARS-CoV-2' named entity 'ACE2' named entity 'single cell sequencing' named entity 'ACE2' named entity 'MTA' named entity 'pseudostratified' named entity 'infection' named entity 'expression levels' named entity '39,778' named entity 'SARS-CoV-2' named entity 'FURIN' named entity 'SARS' named entity 'cell types'

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